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Oxidative stress, mitochondrial damage, and cores in muscle from calsequestrin-1 knockout mice

BACKGROUND: Mutations in the gene encoding ryanodine receptor type-1 (RYR1), the calcium ion (Ca(2+)) release channel in the sarcoplasmic reticulum (SR) of skeletal muscle, are linked to central core disease (CCD) and malignant hyperthermia (MH) susceptibility. We recently reported that mice lacking...

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Detalles Bibliográficos
Autores principales: Paolini, Cecilia, Quarta, Marco, Wei-LaPierre, Lan, Michelucci, Antonio, Nori, Alessandra, Reggiani, Carlo, Dirksen, Robert T, Protasi, Feliciano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464246/
https://www.ncbi.nlm.nih.gov/pubmed/26075051
http://dx.doi.org/10.1186/s13395-015-0035-9