Thiazole formation through a modified Gewald reaction

The synthesis of thiazoles and thiophenes starting from nitriles, via a modified Gewald reaction has been studied for a number of different substrates. 1,4-Dithiane-2,5-diol was used as the aldehyde precursor to give either 2-substituted thiazoles or 2-substituted aminothiophenes depending on the su...

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Detalles Bibliográficos
Autores principales: Mallia, Carl J, Englert, Lukas, Walter, Gary C, Baxendale, Ian R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2015
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464301/
https://www.ncbi.nlm.nih.gov/pubmed/26124889
http://dx.doi.org/10.3762/bjoc.11.98
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author Mallia, Carl J
Englert, Lukas
Walter, Gary C
Baxendale, Ian R
author_facet Mallia, Carl J
Englert, Lukas
Walter, Gary C
Baxendale, Ian R
author_sort Mallia, Carl J
collection PubMed
description The synthesis of thiazoles and thiophenes starting from nitriles, via a modified Gewald reaction has been studied for a number of different substrates. 1,4-Dithiane-2,5-diol was used as the aldehyde precursor to give either 2-substituted thiazoles or 2-substituted aminothiophenes depending on the substitution of the α-carbon to the cyano group.
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spelling pubmed-44643012015-06-29 Thiazole formation through a modified Gewald reaction Mallia, Carl J Englert, Lukas Walter, Gary C Baxendale, Ian R Beilstein J Org Chem Full Research Paper The synthesis of thiazoles and thiophenes starting from nitriles, via a modified Gewald reaction has been studied for a number of different substrates. 1,4-Dithiane-2,5-diol was used as the aldehyde precursor to give either 2-substituted thiazoles or 2-substituted aminothiophenes depending on the substitution of the α-carbon to the cyano group. Beilstein-Institut 2015-05-26 /pmc/articles/PMC4464301/ /pubmed/26124889 http://dx.doi.org/10.3762/bjoc.11.98 Text en Copyright © 2015, Mallia et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Mallia, Carl J
Englert, Lukas
Walter, Gary C
Baxendale, Ian R
Thiazole formation through a modified Gewald reaction
title Thiazole formation through a modified Gewald reaction
title_full Thiazole formation through a modified Gewald reaction
title_fullStr Thiazole formation through a modified Gewald reaction
title_full_unstemmed Thiazole formation through a modified Gewald reaction
title_short Thiazole formation through a modified Gewald reaction
title_sort thiazole formation through a modified gewald reaction
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464301/
https://www.ncbi.nlm.nih.gov/pubmed/26124889
http://dx.doi.org/10.3762/bjoc.11.98
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AT englertlukas thiazoleformationthroughamodifiedgewaldreaction
AT waltergaryc thiazoleformationthroughamodifiedgewaldreaction
AT baxendaleianr thiazoleformationthroughamodifiedgewaldreaction

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