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Climate induces seasonality in pneumococcal transmission
Streptococcus pneumoniae is a significant human pathogen and a leading cause of infant mortality in developing countries. Considerable global variation in the pneumococcal carriage prevalence has been observed and the ecological factors contributing to it are not yet fully understood. We use data fr...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464306/ https://www.ncbi.nlm.nih.gov/pubmed/26067932 http://dx.doi.org/10.1038/srep11344 |
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author | Numminen, Elina Chewapreecha, Claire Turner, Claudia Goldblatt, David Nosten, Francois Bentley, Stephen D. Turner, Paul Corander, Jukka |
author_facet | Numminen, Elina Chewapreecha, Claire Turner, Claudia Goldblatt, David Nosten, Francois Bentley, Stephen D. Turner, Paul Corander, Jukka |
author_sort | Numminen, Elina |
collection | PubMed |
description | Streptococcus pneumoniae is a significant human pathogen and a leading cause of infant mortality in developing countries. Considerable global variation in the pneumococcal carriage prevalence has been observed and the ecological factors contributing to it are not yet fully understood. We use data from a cohort of infants in Asia to study the effects of climatic conditions on both acquisition and clearance rates of the bacterium, finding significantly higher transmissibility during the cooler and drier months. Conversely, the length of a colonization period is unaffected by the season. Independent carriage data from studies conducted on the African and North American continents suggest similar effects of the climate on the prevalence of this bacterium, which further validates the obtained results. Further studies could be important to replicate the findings and explain the mechanistic role of cooler and dry air in the physiological response to nasopharyngeal acquisition of the pneumococcus. |
format | Online Article Text |
id | pubmed-4464306 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-44643062015-06-18 Climate induces seasonality in pneumococcal transmission Numminen, Elina Chewapreecha, Claire Turner, Claudia Goldblatt, David Nosten, Francois Bentley, Stephen D. Turner, Paul Corander, Jukka Sci Rep Article Streptococcus pneumoniae is a significant human pathogen and a leading cause of infant mortality in developing countries. Considerable global variation in the pneumococcal carriage prevalence has been observed and the ecological factors contributing to it are not yet fully understood. We use data from a cohort of infants in Asia to study the effects of climatic conditions on both acquisition and clearance rates of the bacterium, finding significantly higher transmissibility during the cooler and drier months. Conversely, the length of a colonization period is unaffected by the season. Independent carriage data from studies conducted on the African and North American continents suggest similar effects of the climate on the prevalence of this bacterium, which further validates the obtained results. Further studies could be important to replicate the findings and explain the mechanistic role of cooler and dry air in the physiological response to nasopharyngeal acquisition of the pneumococcus. Nature Publishing Group 2015-06-12 /pmc/articles/PMC4464306/ /pubmed/26067932 http://dx.doi.org/10.1038/srep11344 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Numminen, Elina Chewapreecha, Claire Turner, Claudia Goldblatt, David Nosten, Francois Bentley, Stephen D. Turner, Paul Corander, Jukka Climate induces seasonality in pneumococcal transmission |
title | Climate induces seasonality in pneumococcal transmission |
title_full | Climate induces seasonality in pneumococcal transmission |
title_fullStr | Climate induces seasonality in pneumococcal transmission |
title_full_unstemmed | Climate induces seasonality in pneumococcal transmission |
title_short | Climate induces seasonality in pneumococcal transmission |
title_sort | climate induces seasonality in pneumococcal transmission |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464306/ https://www.ncbi.nlm.nih.gov/pubmed/26067932 http://dx.doi.org/10.1038/srep11344 |
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