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Betaine inhibits vascularization via suppression of Akt in the retinas of streptozotocin-induced hyperglycemic rats
Diabetic retinopathy is a severe microvascular complication amongst patients with diabetes, and is the primary cause of visual loss through neovascularization. Betaine is one of the components of Fructus Lycii. In the present study, the effects of betaine on the expression levels of vascular endothe...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464397/ https://www.ncbi.nlm.nih.gov/pubmed/25891515 http://dx.doi.org/10.3892/mmr.2015.3613 |
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author | KIM, YOUNG-GIUN LIM, HYUNG-HO LEE, SUH-HA SHIN, MAL-SOON KIM, CHANG-JU YANG, HYEON JEONG |
author_facet | KIM, YOUNG-GIUN LIM, HYUNG-HO LEE, SUH-HA SHIN, MAL-SOON KIM, CHANG-JU YANG, HYEON JEONG |
author_sort | KIM, YOUNG-GIUN |
collection | PubMed |
description | Diabetic retinopathy is a severe microvascular complication amongst patients with diabetes, and is the primary cause of visual loss through neovascularization. Betaine is one of the components of Fructus Lycii. In the present study, the effects of betaine on the expression levels of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor (HIF)-1α in association with the Akt pathway were investigated in the retinas of streptozotocin (STZ)-induced diabetic rats using western blot and immunohistochemical analyses. The results of the present study revealed that the expression levels of VEGF, HIF-1α, and Akt were increased in the retinas of the STZ-induced diabetic rats. Betaine treatment attenuated this increase in VEGF and HIF-1α expression via suppression of diabetes-induced Akt activation in the retinas of the diabetic rats. The results suggested that betaine may potentially be used to delay the onset of complications associated with diabetic retinopathy via inhibition of retinal neovascularization in patients with diabetes. |
format | Online Article Text |
id | pubmed-4464397 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-44643972015-06-26 Betaine inhibits vascularization via suppression of Akt in the retinas of streptozotocin-induced hyperglycemic rats KIM, YOUNG-GIUN LIM, HYUNG-HO LEE, SUH-HA SHIN, MAL-SOON KIM, CHANG-JU YANG, HYEON JEONG Mol Med Rep Articles Diabetic retinopathy is a severe microvascular complication amongst patients with diabetes, and is the primary cause of visual loss through neovascularization. Betaine is one of the components of Fructus Lycii. In the present study, the effects of betaine on the expression levels of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor (HIF)-1α in association with the Akt pathway were investigated in the retinas of streptozotocin (STZ)-induced diabetic rats using western blot and immunohistochemical analyses. The results of the present study revealed that the expression levels of VEGF, HIF-1α, and Akt were increased in the retinas of the STZ-induced diabetic rats. Betaine treatment attenuated this increase in VEGF and HIF-1α expression via suppression of diabetes-induced Akt activation in the retinas of the diabetic rats. The results suggested that betaine may potentially be used to delay the onset of complications associated with diabetic retinopathy via inhibition of retinal neovascularization in patients with diabetes. D.A. Spandidos 2015-08 2015-04-15 /pmc/articles/PMC4464397/ /pubmed/25891515 http://dx.doi.org/10.3892/mmr.2015.3613 Text en Copyright © 2015, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles KIM, YOUNG-GIUN LIM, HYUNG-HO LEE, SUH-HA SHIN, MAL-SOON KIM, CHANG-JU YANG, HYEON JEONG Betaine inhibits vascularization via suppression of Akt in the retinas of streptozotocin-induced hyperglycemic rats |
title | Betaine inhibits vascularization via suppression of Akt in the retinas of streptozotocin-induced hyperglycemic rats |
title_full | Betaine inhibits vascularization via suppression of Akt in the retinas of streptozotocin-induced hyperglycemic rats |
title_fullStr | Betaine inhibits vascularization via suppression of Akt in the retinas of streptozotocin-induced hyperglycemic rats |
title_full_unstemmed | Betaine inhibits vascularization via suppression of Akt in the retinas of streptozotocin-induced hyperglycemic rats |
title_short | Betaine inhibits vascularization via suppression of Akt in the retinas of streptozotocin-induced hyperglycemic rats |
title_sort | betaine inhibits vascularization via suppression of akt in the retinas of streptozotocin-induced hyperglycemic rats |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464397/ https://www.ncbi.nlm.nih.gov/pubmed/25891515 http://dx.doi.org/10.3892/mmr.2015.3613 |
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