Peptide–polymer ligands for a tandem WW-domain, an adaptive multivalent protein–protein interaction: lessons on the thermodynamic fitness of flexible ligands

Three polymers, poly(N-(2-hydroxypropyl)methacrylamide) (pHPMA), hyperbranched polyglycerol (hPG), and dextran were investigated as carriers for multivalent ligands targeting the adaptive tandem WW-domain of formin-binding protein (FBP21). Polymer carriers were conjugated with 3–9 copies of the prol...

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Detalles Bibliográficos
Autores principales: Koschek, Katharina, Durmaz, Vedat, Krylova, Oxana, Wieczorek, Marek, Gupta, Shilpi, Richter, Martin, Bujotzek, Alexander, Fischer, Christina, Haag, Rainer, Freund, Christian, Weber, Marcus, Rademann, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2015
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464424/
https://www.ncbi.nlm.nih.gov/pubmed/26124884
http://dx.doi.org/10.3762/bjoc.11.93

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