Atrial natriuretic peptide gene - a potential biomarker for long QT syndrome

This study highlights the possible implication of NPPA (natriuretic peptide precursor A) gene in the etiology of Long QT syndrome (LQTS) by population-based as well as familial study. Three SNPs of NPPA - C-664G, C1363A and T1766C were examined by molecular analyses in LQTS, controls and first degre...

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Detalles Bibliográficos
Autores principales: Qureshi, Sameera Fatima, Ali, Altaf, Venkateshwari, Ananthapur, Rao, Hygriv, Jayakrishnan, M. P., Narasimhan, Calambur, Shenthar, Jayaprakash, Thangaraj, Kumarasamy, Nallari, Pratibha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464516/
https://www.ncbi.nlm.nih.gov/pubmed/26417306
Descripción
Sumario:This study highlights the possible implication of NPPA (natriuretic peptide precursor A) gene in the etiology of Long QT syndrome (LQTS) by population-based as well as familial study. Three SNPs of NPPA - C-664G, C1363A and T1766C were examined by molecular analyses in LQTS, controls and first degree relatives (FDRs). This study revealed a possible association of 1364 C>A SNP ‘C’ allele with LQTS (p = 0.0013). All three SNPs were in tight linkage disequilibrium. The familial study highlights the association of NPPA SNP with cLQTS and implicating it as a potential biomarker in South Indian population.

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