Atrial natriuretic peptide gene - a potential biomarker for long QT syndrome

This study highlights the possible implication of NPPA (natriuretic peptide precursor A) gene in the etiology of Long QT syndrome (LQTS) by population-based as well as familial study. Three SNPs of NPPA - C-664G, C1363A and T1766C were examined by molecular analyses in LQTS, controls and first degre...

Descripción completa

Detalles Bibliográficos
Autores principales: Qureshi, Sameera Fatima, Ali, Altaf, Venkateshwari, Ananthapur, Rao, Hygriv, Jayakrishnan, M. P., Narasimhan, Calambur, Shenthar, Jayaprakash, Thangaraj, Kumarasamy, Nallari, Pratibha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464516/
https://www.ncbi.nlm.nih.gov/pubmed/26417306
_version_ 1782375989080227840
author Qureshi, Sameera Fatima
Ali, Altaf
Venkateshwari, Ananthapur
Rao, Hygriv
Jayakrishnan, M. P.
Narasimhan, Calambur
Shenthar, Jayaprakash
Thangaraj, Kumarasamy
Nallari, Pratibha
author_facet Qureshi, Sameera Fatima
Ali, Altaf
Venkateshwari, Ananthapur
Rao, Hygriv
Jayakrishnan, M. P.
Narasimhan, Calambur
Shenthar, Jayaprakash
Thangaraj, Kumarasamy
Nallari, Pratibha
author_sort Qureshi, Sameera Fatima
collection PubMed
description This study highlights the possible implication of NPPA (natriuretic peptide precursor A) gene in the etiology of Long QT syndrome (LQTS) by population-based as well as familial study. Three SNPs of NPPA - C-664G, C1363A and T1766C were examined by molecular analyses in LQTS, controls and first degree relatives (FDRs). This study revealed a possible association of 1364 C>A SNP ‘C’ allele with LQTS (p = 0.0013). All three SNPs were in tight linkage disequilibrium. The familial study highlights the association of NPPA SNP with cLQTS and implicating it as a potential biomarker in South Indian population.
format Online
Article
Text
id pubmed-4464516
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Leibniz Research Centre for Working Environment and Human Factors
record_format MEDLINE/PubMed
spelling pubmed-44645162015-09-28 Atrial natriuretic peptide gene - a potential biomarker for long QT syndrome Qureshi, Sameera Fatima Ali, Altaf Venkateshwari, Ananthapur Rao, Hygriv Jayakrishnan, M. P. Narasimhan, Calambur Shenthar, Jayaprakash Thangaraj, Kumarasamy Nallari, Pratibha EXCLI J Original Article This study highlights the possible implication of NPPA (natriuretic peptide precursor A) gene in the etiology of Long QT syndrome (LQTS) by population-based as well as familial study. Three SNPs of NPPA - C-664G, C1363A and T1766C were examined by molecular analyses in LQTS, controls and first degree relatives (FDRs). This study revealed a possible association of 1364 C>A SNP ‘C’ allele with LQTS (p = 0.0013). All three SNPs were in tight linkage disequilibrium. The familial study highlights the association of NPPA SNP with cLQTS and implicating it as a potential biomarker in South Indian population. Leibniz Research Centre for Working Environment and Human Factors 2014-08-13 /pmc/articles/PMC4464516/ /pubmed/26417306 Text en Copyright © 2014 Qureshi et al. http://www.excli.de/documents/assignment_of_rights.pdf This is an Open Access article distributed under the following Assignment of Rights http://www.excli.de/documents/assignment_of_rights.pdf. You are free to copy, distribute and transmit the work, provided the original author and source are credited.
spellingShingle Original Article
Qureshi, Sameera Fatima
Ali, Altaf
Venkateshwari, Ananthapur
Rao, Hygriv
Jayakrishnan, M. P.
Narasimhan, Calambur
Shenthar, Jayaprakash
Thangaraj, Kumarasamy
Nallari, Pratibha
Atrial natriuretic peptide gene - a potential biomarker for long QT syndrome
title Atrial natriuretic peptide gene - a potential biomarker for long QT syndrome
title_full Atrial natriuretic peptide gene - a potential biomarker for long QT syndrome
title_fullStr Atrial natriuretic peptide gene - a potential biomarker for long QT syndrome
title_full_unstemmed Atrial natriuretic peptide gene - a potential biomarker for long QT syndrome
title_short Atrial natriuretic peptide gene - a potential biomarker for long QT syndrome
title_sort atrial natriuretic peptide gene - a potential biomarker for long qt syndrome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464516/
https://www.ncbi.nlm.nih.gov/pubmed/26417306
work_keys_str_mv AT qureshisameerafatima atrialnatriureticpeptidegeneapotentialbiomarkerforlongqtsyndrome
AT alialtaf atrialnatriureticpeptidegeneapotentialbiomarkerforlongqtsyndrome
AT venkateshwariananthapur atrialnatriureticpeptidegeneapotentialbiomarkerforlongqtsyndrome
AT raohygriv atrialnatriureticpeptidegeneapotentialbiomarkerforlongqtsyndrome
AT jayakrishnanmp atrialnatriureticpeptidegeneapotentialbiomarkerforlongqtsyndrome
AT narasimhancalambur atrialnatriureticpeptidegeneapotentialbiomarkerforlongqtsyndrome
AT shentharjayaprakash atrialnatriureticpeptidegeneapotentialbiomarkerforlongqtsyndrome
AT thangarajkumarasamy atrialnatriureticpeptidegeneapotentialbiomarkerforlongqtsyndrome
AT nallaripratibha atrialnatriureticpeptidegeneapotentialbiomarkerforlongqtsyndrome

Ejemplares similares