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Atrial natriuretic peptide gene - a potential biomarker for long QT syndrome
This study highlights the possible implication of NPPA (natriuretic peptide precursor A) gene in the etiology of Long QT syndrome (LQTS) by population-based as well as familial study. Three SNPs of NPPA - C-664G, C1363A and T1766C were examined by molecular analyses in LQTS, controls and first degre...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Leibniz Research Centre for Working Environment and Human Factors
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464516/ https://www.ncbi.nlm.nih.gov/pubmed/26417306 |
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author | Qureshi, Sameera Fatima Ali, Altaf Venkateshwari, Ananthapur Rao, Hygriv Jayakrishnan, M. P. Narasimhan, Calambur Shenthar, Jayaprakash Thangaraj, Kumarasamy Nallari, Pratibha |
author_facet | Qureshi, Sameera Fatima Ali, Altaf Venkateshwari, Ananthapur Rao, Hygriv Jayakrishnan, M. P. Narasimhan, Calambur Shenthar, Jayaprakash Thangaraj, Kumarasamy Nallari, Pratibha |
author_sort | Qureshi, Sameera Fatima |
collection | PubMed |
description | This study highlights the possible implication of NPPA (natriuretic peptide precursor A) gene in the etiology of Long QT syndrome (LQTS) by population-based as well as familial study. Three SNPs of NPPA - C-664G, C1363A and T1766C were examined by molecular analyses in LQTS, controls and first degree relatives (FDRs). This study revealed a possible association of 1364 C>A SNP ‘C’ allele with LQTS (p = 0.0013). All three SNPs were in tight linkage disequilibrium. The familial study highlights the association of NPPA SNP with cLQTS and implicating it as a potential biomarker in South Indian population. |
format | Online Article Text |
id | pubmed-4464516 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Leibniz Research Centre for Working Environment and Human Factors |
record_format | MEDLINE/PubMed |
spelling | pubmed-44645162015-09-28 Atrial natriuretic peptide gene - a potential biomarker for long QT syndrome Qureshi, Sameera Fatima Ali, Altaf Venkateshwari, Ananthapur Rao, Hygriv Jayakrishnan, M. P. Narasimhan, Calambur Shenthar, Jayaprakash Thangaraj, Kumarasamy Nallari, Pratibha EXCLI J Original Article This study highlights the possible implication of NPPA (natriuretic peptide precursor A) gene in the etiology of Long QT syndrome (LQTS) by population-based as well as familial study. Three SNPs of NPPA - C-664G, C1363A and T1766C were examined by molecular analyses in LQTS, controls and first degree relatives (FDRs). This study revealed a possible association of 1364 C>A SNP ‘C’ allele with LQTS (p = 0.0013). All three SNPs were in tight linkage disequilibrium. The familial study highlights the association of NPPA SNP with cLQTS and implicating it as a potential biomarker in South Indian population. Leibniz Research Centre for Working Environment and Human Factors 2014-08-13 /pmc/articles/PMC4464516/ /pubmed/26417306 Text en Copyright © 2014 Qureshi et al. http://www.excli.de/documents/assignment_of_rights.pdf This is an Open Access article distributed under the following Assignment of Rights http://www.excli.de/documents/assignment_of_rights.pdf. You are free to copy, distribute and transmit the work, provided the original author and source are credited. |
spellingShingle | Original Article Qureshi, Sameera Fatima Ali, Altaf Venkateshwari, Ananthapur Rao, Hygriv Jayakrishnan, M. P. Narasimhan, Calambur Shenthar, Jayaprakash Thangaraj, Kumarasamy Nallari, Pratibha Atrial natriuretic peptide gene - a potential biomarker for long QT syndrome |
title | Atrial natriuretic peptide gene - a potential biomarker for long QT syndrome |
title_full | Atrial natriuretic peptide gene - a potential biomarker for long QT syndrome |
title_fullStr | Atrial natriuretic peptide gene - a potential biomarker for long QT syndrome |
title_full_unstemmed | Atrial natriuretic peptide gene - a potential biomarker for long QT syndrome |
title_short | Atrial natriuretic peptide gene - a potential biomarker for long QT syndrome |
title_sort | atrial natriuretic peptide gene - a potential biomarker for long qt syndrome |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464516/ https://www.ncbi.nlm.nih.gov/pubmed/26417306 |
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