Oxidative stress alters global histone modification and DNA methylation

The JmjC-domain-containing histone demethylases (JHDMs) can remove histone lysine-methylation and thereby regulate gene expression. The JmjC-domain uses iron Fe (II) and α-ketoglutarate (αKG) as cofactors in an oxidative demethylation reaction via hydroxymethyl-lysine. We hypothesize that reactive o...

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Detalles Bibliográficos
Autores principales: Niu, Yingmei, DesMarais, Thomas L, Tong, Zhaohui, Yao, Yixin, Costa, Max
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464695/
https://www.ncbi.nlm.nih.gov/pubmed/25656994
http://dx.doi.org/10.1016/j.freeradbiomed.2015.01.028

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