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Techniques for early diagnosis of oral squamous cell carcinoma: Systematic review

BACKGROUND AND OBJECTIVES: The diagnosis of early oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC) is of paramount clinical importance given the mortality rate of late stage disease. The aim of this study is to review the literature to assess the current situation...

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Autores principales: Carreras-Torras, Clàudia, Gay-Escoda, Cosme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medicina Oral S.L. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464918/
https://www.ncbi.nlm.nih.gov/pubmed/25662554
http://dx.doi.org/10.4317/medoral.20347
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author Carreras-Torras, Clàudia
Gay-Escoda, Cosme
author_facet Carreras-Torras, Clàudia
Gay-Escoda, Cosme
author_sort Carreras-Torras, Clàudia
collection PubMed
description BACKGROUND AND OBJECTIVES: The diagnosis of early oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC) is of paramount clinical importance given the mortality rate of late stage disease. The aim of this study is to review the literature to assess the current situation and progress in this area. MATERIAL AND METHODS: A search in Cochrane and PubMed (January 2006 to December 2013) has been used with the key words “squamous cell carcinoma”, “early diagnosis” “oral cavity”, “Potentially Malignant Disorders” y “premalignant lesions”. The inclusion criteria were the use of techniques for early diagnosis of OSCC and OPMD, 7 years aged articles and publications written in English, French or Spanish. The exclusion criteria were case reports and studies in other languages. RESULTS: Out of the 89 studies obtained initially from the search 60 articles were selected to be included in the systematic review: 1 metaanalysis, 17 systematic reviews, 35 prospective studies, 5 retrospective studies, 1 consensus and 1 semi-structured interviews. CONCLUSIONS: The best diagnostic technique is that which we have sufficient experience and training. Definitely tissue biopsy and histopathological examination should remain the gold standard for oral cancer diagnose. In this systematic review it has not been found sufficient scientific evidence on the majority of proposed techniques for early diagnosis of OSCC, therefore more extensive and exhaustive studies are needed. Key words: Squamous cell carcinoma, early diagnosis, oral cavity, potentially malignant disorders, premalignant lesions.
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spelling pubmed-44649182015-06-16 Techniques for early diagnosis of oral squamous cell carcinoma: Systematic review Carreras-Torras, Clàudia Gay-Escoda, Cosme Med Oral Patol Oral Cir Bucal Review BACKGROUND AND OBJECTIVES: The diagnosis of early oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC) is of paramount clinical importance given the mortality rate of late stage disease. The aim of this study is to review the literature to assess the current situation and progress in this area. MATERIAL AND METHODS: A search in Cochrane and PubMed (January 2006 to December 2013) has been used with the key words “squamous cell carcinoma”, “early diagnosis” “oral cavity”, “Potentially Malignant Disorders” y “premalignant lesions”. The inclusion criteria were the use of techniques for early diagnosis of OSCC and OPMD, 7 years aged articles and publications written in English, French or Spanish. The exclusion criteria were case reports and studies in other languages. RESULTS: Out of the 89 studies obtained initially from the search 60 articles were selected to be included in the systematic review: 1 metaanalysis, 17 systematic reviews, 35 prospective studies, 5 retrospective studies, 1 consensus and 1 semi-structured interviews. CONCLUSIONS: The best diagnostic technique is that which we have sufficient experience and training. Definitely tissue biopsy and histopathological examination should remain the gold standard for oral cancer diagnose. In this systematic review it has not been found sufficient scientific evidence on the majority of proposed techniques for early diagnosis of OSCC, therefore more extensive and exhaustive studies are needed. Key words: Squamous cell carcinoma, early diagnosis, oral cavity, potentially malignant disorders, premalignant lesions. Medicina Oral S.L. 2015-05 2015-02-07 /pmc/articles/PMC4464918/ /pubmed/25662554 http://dx.doi.org/10.4317/medoral.20347 Text en Copyright: © 2015 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Carreras-Torras, Clàudia
Gay-Escoda, Cosme
Techniques for early diagnosis of oral squamous cell carcinoma: Systematic review
title Techniques for early diagnosis of oral squamous cell carcinoma: Systematic review
title_full Techniques for early diagnosis of oral squamous cell carcinoma: Systematic review
title_fullStr Techniques for early diagnosis of oral squamous cell carcinoma: Systematic review
title_full_unstemmed Techniques for early diagnosis of oral squamous cell carcinoma: Systematic review
title_short Techniques for early diagnosis of oral squamous cell carcinoma: Systematic review
title_sort techniques for early diagnosis of oral squamous cell carcinoma: systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464918/
https://www.ncbi.nlm.nih.gov/pubmed/25662554
http://dx.doi.org/10.4317/medoral.20347
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