MiRNA-based therapeutic intervention of cancer

MicroRNAs (miRNAs) are important modulators of eukaryotic gene expression. By targeting protein coding transcripts, miRNAs influence the cellular transcriptome and proteome, thus helping to determine cell fate. MiRNAs have emerged as crucial molecules in cancer research, in which recent studies have...

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Detalles Bibliográficos
Autores principales: Naidu, Srivatsava, Magee, Peter, Garofalo, Michela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465004/
https://www.ncbi.nlm.nih.gov/pubmed/26062952
http://dx.doi.org/10.1186/s13045-015-0162-0
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author Naidu, Srivatsava
Magee, Peter
Garofalo, Michela
author_facet Naidu, Srivatsava
Magee, Peter
Garofalo, Michela
author_sort Naidu, Srivatsava
collection PubMed
description MicroRNAs (miRNAs) are important modulators of eukaryotic gene expression. By targeting protein coding transcripts, miRNAs influence the cellular transcriptome and proteome, thus helping to determine cell fate. MiRNAs have emerged as crucial molecules in cancer research, in which recent studies have linked erratic expression of miRNAs to carcinogenesis and have provided solid evidence for their potential in cancer therapy. This review briefly summarises the recent knowledge on the involvement of miRNAs in tumourigenesis and reviews current studies on the therapeutic strategies and advances in the delivery of miRNAs.
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spelling pubmed-44650042015-06-14 MiRNA-based therapeutic intervention of cancer Naidu, Srivatsava Magee, Peter Garofalo, Michela J Hematol Oncol Review MicroRNAs (miRNAs) are important modulators of eukaryotic gene expression. By targeting protein coding transcripts, miRNAs influence the cellular transcriptome and proteome, thus helping to determine cell fate. MiRNAs have emerged as crucial molecules in cancer research, in which recent studies have linked erratic expression of miRNAs to carcinogenesis and have provided solid evidence for their potential in cancer therapy. This review briefly summarises the recent knowledge on the involvement of miRNAs in tumourigenesis and reviews current studies on the therapeutic strategies and advances in the delivery of miRNAs. BioMed Central 2015-06-11 /pmc/articles/PMC4465004/ /pubmed/26062952 http://dx.doi.org/10.1186/s13045-015-0162-0 Text en © Naidu et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Naidu, Srivatsava
Magee, Peter
Garofalo, Michela
MiRNA-based therapeutic intervention of cancer
title MiRNA-based therapeutic intervention of cancer
title_full MiRNA-based therapeutic intervention of cancer
title_fullStr MiRNA-based therapeutic intervention of cancer
title_full_unstemmed MiRNA-based therapeutic intervention of cancer
title_short MiRNA-based therapeutic intervention of cancer
title_sort mirna-based therapeutic intervention of cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465004/
https://www.ncbi.nlm.nih.gov/pubmed/26062952
http://dx.doi.org/10.1186/s13045-015-0162-0
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