Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease

Development of therapeutic strategies to prevent Alzheimer's disease (AD) is of great importance. We show that mild inhibition of mitochondrial complex I with small molecule CP2 reduces levels of amyloid beta and phospho-Tau and averts cognitive decline in three animal models of familial AD. Lo...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Liang, Zhang, Song, Maezawa, Izumi, Trushin, Sergey, Minhas, Paras, Pinto, Matthew, Jin, Lee-Way, Prasain, Keshar, Nguyen, Thi D.T., Yamazaki, Yu, Kanekiyo, Takahisa, Bu, Guojun, Gateno, Benjamin, Chang, Kyeong-Ok, Nath, Karl A., Nemutlu, Emirhan, Dzeja, Petras, Pang, Yuan-Ping, Hua, Duy H., Trushina, Eugenia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465115/
https://www.ncbi.nlm.nih.gov/pubmed/26086035
http://dx.doi.org/10.1016/j.ebiom.2015.03.009

Ejemplares similares

Ejemplares similares