A versatile reporter system for CRISPR-mediated chromosomal rearrangements

Although chromosomal deletions and inversions are important in cancer, conventional methods for detecting DNA rearrangements require laborious indirect assays. Here we develop fluorescent reporters to rapidly quantify CRISPR/Cas9-mediated deletions and inversions. We find that inversion depends on t...

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Detalles Bibliográficos
Autores principales: Li, Yingxiang, Park, Angela I., Mou, Haiwei, Colpan, Cansu, Bizhanova, Aizhan, Akama-Garren, Elliot, Joshi, Nik, Hendrickson, Eric A., Feldser, David, Yin, Hao, Anderson, Daniel G., Jacks, Tyler, Weng, Zhiping, Xue, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465146/
https://www.ncbi.nlm.nih.gov/pubmed/26018130
http://dx.doi.org/10.1186/s13059-015-0680-7

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