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Antibody engineering for increased potency, breadth and half-life

PURPOSE OF REVIEW: This review highlights recent developments in HIV-1 antibody engineering and discusses the effects of increased polyreactivity on serum half-lives of engineered antibodies. RECENT FINDINGS: Recent studies have uncovered a wealth of information about the relationship between the se...

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Detalles Bibliográficos
Autores principales:	Sievers, Stuart A., Scharf, Louise, West, Anthony P., Bjorkman, Pamela J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2015
Materias:	ANTIBODIES FOR PREVENTION AND THERAPY: Edited by John R. Mascola and Richard A. Koup
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465343/ https://www.ncbi.nlm.nih.gov/pubmed/25760931 http://dx.doi.org/10.1097/COH.0000000000000148

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