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Emotion Reactivity Is Increased 4-6 Weeks Postpartum in Healthy Women: A Longitudinal fMRI Study

Marked endocrine alterations occur after delivery. Most women cope well with these changes, but the postpartum period is associated with an increased risk of depressive episodes. Previous studies of emotion processing have focused on maternal–infant bonding or postpartum depression (PPD), and longit...

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Autores principales: Gingnell, Malin, Bannbers, Elin, Moes, Harmen, Engman, Jonas, Sylvén, Sara, Skalkidou, Alkistis, Kask, Kristiina, Wikström, Johan, Sundström-Poromaa, Inger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465482/
https://www.ncbi.nlm.nih.gov/pubmed/26061879
http://dx.doi.org/10.1371/journal.pone.0128964
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author Gingnell, Malin
Bannbers, Elin
Moes, Harmen
Engman, Jonas
Sylvén, Sara
Skalkidou, Alkistis
Kask, Kristiina
Wikström, Johan
Sundström-Poromaa, Inger
author_facet Gingnell, Malin
Bannbers, Elin
Moes, Harmen
Engman, Jonas
Sylvén, Sara
Skalkidou, Alkistis
Kask, Kristiina
Wikström, Johan
Sundström-Poromaa, Inger
author_sort Gingnell, Malin
collection PubMed
description Marked endocrine alterations occur after delivery. Most women cope well with these changes, but the postpartum period is associated with an increased risk of depressive episodes. Previous studies of emotion processing have focused on maternal–infant bonding or postpartum depression (PPD), and longitudinal studies of the neural correlates of emotion processing throughout the postpartum period in healthy women are lacking. In this study, 13 women, without signs of post partum depression, underwent fMRI with an emotional face matching task and completed the MADRS-S, STAI-S, and EPDS within 48 h (early postpartum) and 4–6 weeks after delivery (late postpartum). Also, data from a previous study including 15 naturally cycling controls assessed in the luteal and follicular phase of the menstrual cycle was used. Women had lower reactivity in insula, middle frontal gyrus (MFG), and inferior frontal gyrus (IFG) in the early as compared to the late postpartum assessment. Insular reactivity was positively correlated with anxiety in the early postpartum period and with depressive symptoms late postpartum. Reactivity in insula and IFG were greater in postpartum women than in non-pregnant control subjects. Brain reactivity was not correlated with serum estradiol or progesterone levels. Increased reactivity in the insula, IFG, and MFG may reflect normal postpartum adaptation, but correlation with self-rated symptoms of depression and anxiety in these otherwise healthy postpartum women, may also suggest that these changes place susceptible women at increased risk of PPD. These findings contribute to our understanding of the neurobiological aspects of the postpartum period, which might shed light on the mechanisms underlying affective puerperal disorders, such as PPD.
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spelling pubmed-44654822015-06-25 Emotion Reactivity Is Increased 4-6 Weeks Postpartum in Healthy Women: A Longitudinal fMRI Study Gingnell, Malin Bannbers, Elin Moes, Harmen Engman, Jonas Sylvén, Sara Skalkidou, Alkistis Kask, Kristiina Wikström, Johan Sundström-Poromaa, Inger PLoS One Research Article Marked endocrine alterations occur after delivery. Most women cope well with these changes, but the postpartum period is associated with an increased risk of depressive episodes. Previous studies of emotion processing have focused on maternal–infant bonding or postpartum depression (PPD), and longitudinal studies of the neural correlates of emotion processing throughout the postpartum period in healthy women are lacking. In this study, 13 women, without signs of post partum depression, underwent fMRI with an emotional face matching task and completed the MADRS-S, STAI-S, and EPDS within 48 h (early postpartum) and 4–6 weeks after delivery (late postpartum). Also, data from a previous study including 15 naturally cycling controls assessed in the luteal and follicular phase of the menstrual cycle was used. Women had lower reactivity in insula, middle frontal gyrus (MFG), and inferior frontal gyrus (IFG) in the early as compared to the late postpartum assessment. Insular reactivity was positively correlated with anxiety in the early postpartum period and with depressive symptoms late postpartum. Reactivity in insula and IFG were greater in postpartum women than in non-pregnant control subjects. Brain reactivity was not correlated with serum estradiol or progesterone levels. Increased reactivity in the insula, IFG, and MFG may reflect normal postpartum adaptation, but correlation with self-rated symptoms of depression and anxiety in these otherwise healthy postpartum women, may also suggest that these changes place susceptible women at increased risk of PPD. These findings contribute to our understanding of the neurobiological aspects of the postpartum period, which might shed light on the mechanisms underlying affective puerperal disorders, such as PPD. Public Library of Science 2015-06-10 /pmc/articles/PMC4465482/ /pubmed/26061879 http://dx.doi.org/10.1371/journal.pone.0128964 Text en © 2015 Gingnell et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Gingnell, Malin
Bannbers, Elin
Moes, Harmen
Engman, Jonas
Sylvén, Sara
Skalkidou, Alkistis
Kask, Kristiina
Wikström, Johan
Sundström-Poromaa, Inger
Emotion Reactivity Is Increased 4-6 Weeks Postpartum in Healthy Women: A Longitudinal fMRI Study
title Emotion Reactivity Is Increased 4-6 Weeks Postpartum in Healthy Women: A Longitudinal fMRI Study
title_full Emotion Reactivity Is Increased 4-6 Weeks Postpartum in Healthy Women: A Longitudinal fMRI Study
title_fullStr Emotion Reactivity Is Increased 4-6 Weeks Postpartum in Healthy Women: A Longitudinal fMRI Study
title_full_unstemmed Emotion Reactivity Is Increased 4-6 Weeks Postpartum in Healthy Women: A Longitudinal fMRI Study
title_short Emotion Reactivity Is Increased 4-6 Weeks Postpartum in Healthy Women: A Longitudinal fMRI Study
title_sort emotion reactivity is increased 4-6 weeks postpartum in healthy women: a longitudinal fmri study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465482/
https://www.ncbi.nlm.nih.gov/pubmed/26061879
http://dx.doi.org/10.1371/journal.pone.0128964
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