Cargando…

Therapeutic Touch Has Significant Effects on Mouse Breast Cancer Metastasis and Immune Responses but Not Primary Tumor Size

Evidence-based integrative medicine therapies have been introduced to promote wellness and offset side-effects from cancer treatment. Energy medicine is an integrative medicine technique using the human biofield to promote well-being. The biofield therapy chosen for study was Therapeutic Touch (TT)....

Descripción completa

Detalles Bibliográficos
Autores principales: Gronowicz, Gloria, Secor, Eric R., Flynn, John R., Jellison, Evan R., Kuhn, Liisa T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465772/
https://www.ncbi.nlm.nih.gov/pubmed/26113869
http://dx.doi.org/10.1155/2015/926565
_version_ 1782376135148961792
author Gronowicz, Gloria
Secor, Eric R.
Flynn, John R.
Jellison, Evan R.
Kuhn, Liisa T.
author_facet Gronowicz, Gloria
Secor, Eric R.
Flynn, John R.
Jellison, Evan R.
Kuhn, Liisa T.
author_sort Gronowicz, Gloria
collection PubMed
description Evidence-based integrative medicine therapies have been introduced to promote wellness and offset side-effects from cancer treatment. Energy medicine is an integrative medicine technique using the human biofield to promote well-being. The biofield therapy chosen for study was Therapeutic Touch (TT). Breast cancer tumors were initiated in mice by injection of metastatic 66cl4 mammary carcinoma cells. The control group received only vehicle. TT or mock treatments were performed twice a week for 10 minutes. Two experienced TT practitioners alternated treatments. At 26 days, metastasis to popliteal lymph nodes was determined by clonogenic assay. Changes in immune function were measured by analysis of serum cytokines and by fluorescent activated cells sorting (FACS) of immune cells from the spleen and lymph nodes. No significant differences were found in body weight gain or tumor size. Metastasis was significantly reduced in the TT-treated mice compared to mock-treated mice. Cancer significantly elevated eleven cytokines. TT significantly reduced IL-1-a, MIG, IL-1b, and MIP-2 to control/vehicle levels. FACS demonstrated that TT significantly reduced specific splenic lymphocyte subsets and macrophages were significantly elevated with cancer. Human biofield therapy had no significant effect on primary tumor but produced significant effects on metastasis and immune responses in a mouse breast cancer model.
format Online
Article
Text
id pubmed-4465772
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-44657722015-06-25 Therapeutic Touch Has Significant Effects on Mouse Breast Cancer Metastasis and Immune Responses but Not Primary Tumor Size Gronowicz, Gloria Secor, Eric R. Flynn, John R. Jellison, Evan R. Kuhn, Liisa T. Evid Based Complement Alternat Med Research Article Evidence-based integrative medicine therapies have been introduced to promote wellness and offset side-effects from cancer treatment. Energy medicine is an integrative medicine technique using the human biofield to promote well-being. The biofield therapy chosen for study was Therapeutic Touch (TT). Breast cancer tumors were initiated in mice by injection of metastatic 66cl4 mammary carcinoma cells. The control group received only vehicle. TT or mock treatments were performed twice a week for 10 minutes. Two experienced TT practitioners alternated treatments. At 26 days, metastasis to popliteal lymph nodes was determined by clonogenic assay. Changes in immune function were measured by analysis of serum cytokines and by fluorescent activated cells sorting (FACS) of immune cells from the spleen and lymph nodes. No significant differences were found in body weight gain or tumor size. Metastasis was significantly reduced in the TT-treated mice compared to mock-treated mice. Cancer significantly elevated eleven cytokines. TT significantly reduced IL-1-a, MIG, IL-1b, and MIP-2 to control/vehicle levels. FACS demonstrated that TT significantly reduced specific splenic lymphocyte subsets and macrophages were significantly elevated with cancer. Human biofield therapy had no significant effect on primary tumor but produced significant effects on metastasis and immune responses in a mouse breast cancer model. Hindawi Publishing Corporation 2015 2015-05-31 /pmc/articles/PMC4465772/ /pubmed/26113869 http://dx.doi.org/10.1155/2015/926565 Text en Copyright © 2015 Gloria Gronowicz et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gronowicz, Gloria
Secor, Eric R.
Flynn, John R.
Jellison, Evan R.
Kuhn, Liisa T.
Therapeutic Touch Has Significant Effects on Mouse Breast Cancer Metastasis and Immune Responses but Not Primary Tumor Size
title Therapeutic Touch Has Significant Effects on Mouse Breast Cancer Metastasis and Immune Responses but Not Primary Tumor Size
title_full Therapeutic Touch Has Significant Effects on Mouse Breast Cancer Metastasis and Immune Responses but Not Primary Tumor Size
title_fullStr Therapeutic Touch Has Significant Effects on Mouse Breast Cancer Metastasis and Immune Responses but Not Primary Tumor Size
title_full_unstemmed Therapeutic Touch Has Significant Effects on Mouse Breast Cancer Metastasis and Immune Responses but Not Primary Tumor Size
title_short Therapeutic Touch Has Significant Effects on Mouse Breast Cancer Metastasis and Immune Responses but Not Primary Tumor Size
title_sort therapeutic touch has significant effects on mouse breast cancer metastasis and immune responses but not primary tumor size
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465772/
https://www.ncbi.nlm.nih.gov/pubmed/26113869
http://dx.doi.org/10.1155/2015/926565
work_keys_str_mv AT gronowiczgloria therapeutictouchhassignificanteffectsonmousebreastcancermetastasisandimmuneresponsesbutnotprimarytumorsize
AT secorericr therapeutictouchhassignificanteffectsonmousebreastcancermetastasisandimmuneresponsesbutnotprimarytumorsize
AT flynnjohnr therapeutictouchhassignificanteffectsonmousebreastcancermetastasisandimmuneresponsesbutnotprimarytumorsize
AT jellisonevanr therapeutictouchhassignificanteffectsonmousebreastcancermetastasisandimmuneresponsesbutnotprimarytumorsize
AT kuhnliisat therapeutictouchhassignificanteffectsonmousebreastcancermetastasisandimmuneresponsesbutnotprimarytumorsize