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Comparison of Gating Properties and Use-Dependent Block of Na(v)1.5 and Na(v)1.7 Channels by Anti-Arrhythmics Mexiletine and Lidocaine

Mexiletine and lidocaine are widely used class IB anti-arrhythmic drugs that are considered to act by blocking voltage-gated open sodium currents for treatment of ventricular arrhythmias and relief of pain. To gain mechanistic insights into action of anti-arrhythmics, we characterized biophysical pr...

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Detalles Bibliográficos
Autores principales:	Wang, Ying, Mi, Jianxun, Lu, Ka, Lu, Yanxin, Wang, KeWei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465899/ https://www.ncbi.nlm.nih.gov/pubmed/26068619 http://dx.doi.org/10.1371/journal.pone.0128653

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