The MS Risk Allele of CD40 Is Associated with Reduced Cell-Membrane Bound Expression in Antigen Presenting Cells: Implications for Gene Function

Human genetic and animal studies have implicated the costimulatory molecule CD40 in the development of multiple sclerosis (MS). We investigated the cell specific gene and protein expression variation controlled by the CD40 genetic variant(s) associated with MS, i.e. the T-allele at rs1883832. Previo...

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Detalles Bibliográficos
Autores principales: Field, Judith, Shahijanian, Fernando, Schibeci, Stephen, Johnson, Laura, Gresle, Melissa, Laverick, Louise, Parnell, Grant, Stewart, Graeme, McKay, Fiona, Kilpatrick, Trevor, Butzkueven, Helmut, Booth, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465929/
https://www.ncbi.nlm.nih.gov/pubmed/26068105
http://dx.doi.org/10.1371/journal.pone.0127080

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