Cargando…

Dynamics of the Peripheral Membrane Protein P2 from Human Myelin Measured by Neutron Scattering—A Comparison between Wild-Type Protein and a Hinge Mutant

Myelin protein P2 is a fatty acid-binding structural component of the myelin sheath in the peripheral nervous system, and its function is related to its membrane binding capacity. Here, the link between P2 protein dynamics and structure and function was studied using elastic incoherent neutron scatt...

Descripción completa

Detalles Bibliográficos
Autores principales:	Laulumaa, Saara, Nieminen, Tuomo, Lehtimäki, Mari, Aggarwal, Shweta, Simons, Mikael, Koza, Michael M., Vattulainen, Ilpo, Kursula, Petri, Natali, Francesca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466134/ https://www.ncbi.nlm.nih.gov/pubmed/26068118 http://dx.doi.org/10.1371/journal.pone.0128954

Ejemplares similares

Structure and dynamics of a human myelin protein P2 portal region mutant indicate opening of the β barrel in fatty acid binding proteins
por: Laulumaa, Saara, et al.
Publicado: (2018)

Atomic resolution view into the structure–function relationships of the human myelin peripheral membrane protein P2
por: Ruskamo, Salla, et al.
Publicado: (2013)

Determinants of ligand binding and catalytic activity in the myelin enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase
por: Raasakka, Arne, et al.
Publicado: (2015)

Molecular mechanisms of Charcot-Marie-Tooth neuropathy linked to mutations in human myelin protein P2
por: Ruskamo, Salla, et al.
Publicado: (2017)

Publisher Correction: Molecular mechanisms of Charcot-Marie-Tooth neuropathy linked to mutations in human myelin protein P2
por: Ruskamo, Salla, et al.
Publicado: (2018)

Sub-Atomic Resolution Crystal Structures Reveal Conserved Geometric Outliers at Functional Sites
por: Laulumaa, Saara, et al.
Publicado: (2019)

Multiple sclerosis and myelin basic protein: insights into protein disorder and disease
por: Martinsen, Vebjørn, et al.
Publicado: (2021)

How Does Protein Zero Assemble Compact Myelin?
por: Raasakka, Arne, et al.
Publicado: (2020)

Structural and Functional Characterization of Human Peripheral Nervous System Myelin Protein P2
por: Majava, Viivi, et al.
Publicado: (2010)

Flexible Players within the Sheaths: The Intrinsically Disordered Proteins of Myelin in Health and Disease
por: Raasakka, Arne, et al.
Publicado: (2020)

Crystallographic anomalous diffraction data for the experimental phasing of two myelin proteins, gliomedin and periaxin
por: Han, Huijong, et al.
Publicado: (2017)

Myelin Membrane Assembly Is Driven by a Phase Transition of Myelin Basic Proteins Into a Cohesive Protein Meshwork
por: Aggarwal, Shweta, et al.
Publicado: (2013)

Correction: Raasakka, A.; Kursula, P. Flexible Players within the Sheaths: The Intrinsically Disordered Proteins of Myelin in Health and Disease. Cells 2020, 9, 470
por: Raasakka, Arne, et al.
Publicado: (2022)

The intrinsically disordered protein glue of the myelin major dense line: Linking AlphaFold2 predictions to experimental data
por: Krokengen, Oda C., et al.
Publicado: (2023)

Human myelin proteolipid protein structure and lipid bilayer stacking
por: Ruskamo, Salla, et al.
Publicado: (2022)

Membrane Association Landscape of Myelin Basic Protein Portrays Formation of the Myelin Major Dense Line
por: Raasakka, Arne, et al.
Publicado: (2017)

Charge Isomers of Myelin Basic Protein: Structure and Interactions with Membranes, Nucleotide Analogues, and Calmodulin
por: Wang, Chaozhan, et al.
Publicado: (2011)

Lipid Exchange Mechanism of the Cholesteryl Ester Transfer Protein Clarified by Atomistic and Coarse-grained Simulations
por: Koivuniemi, Artturi, et al.
Publicado: (2012)

Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin
por: Snaidero, Nicolas, et al.
Publicado: (2017)

Interaction between the C-terminal region of human myelin basic protein and calmodulin: analysis of complex formation and solution structure
por: Majava, Viivi, et al.
Publicado: (2008)

Molecular structure and function of myelin protein P0 in membrane stacking
por: Raasakka, Arne, et al.
Publicado: (2019)

Structural similarities and functional differences clarify evolutionary relationships between tRNA healing enzymes and the myelin enzyme CNPase
por: Muruganandam, Gopinath, et al.
Publicado: (2017)

Neutron scattering from myelin revisited: bilayer asymmetry and water-exchange kinetics
por: Denninger, Andrew R., et al.
Publicado: (2014)

Excessive aggregation of membrane proteins in the Martini model
por: Javanainen, Matti, et al.
Publicado: (2017)

Commander Complex—A Multifaceted Operator in Intracellular Signaling and Cargo
por: Laulumaa, Saara, et al.
Publicado: (2021)

Protein Crowding and Cholesterol Increase Cell Membrane Viscosity in a Temperature Dependent Manner
por: Fábián, Balázs, et al.
Publicado: (2023)

Expression, purification, and initial characterization of different domains of recombinant mouse 2',3'-cyclic nucleotide 3'-phosphodiesterase, an enigmatic enzyme from the myelin sheath
por: Myllykoski, Matti, et al.
Publicado: (2010)

Myelin 2′,3′-Cyclic Nucleotide 3′-Phosphodiesterase: Active-Site Ligand Binding and Molecular Conformation
por: Myllykoski, Matti, et al.
Publicado: (2012)

Computational prediction of hinge axes in proteins
por: Shamsuddin, Rittika, et al.
Publicado: (2014)

Diffusion in dense supercritical methane from quasi-elastic neutron scattering measurements
por: Ranieri, Umbertoluca, et al.
Publicado: (2021)

Assembly of Myelin by Association of Proteolipid Protein with Cholesterol- and Galactosylceramide-Rich Membrane Domains
por: Simons, Mikael, et al.
Publicado: (2000)

Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases
por: Weil, Marie-Theres, et al.
Publicado: (2016)

Structure and function of an atypical homodimeric actin capping protein from the malaria parasite
por: Bendes, Ábris Ádám, et al.
Publicado: (2022)

Assessment of mutation probabilities of KRAS G12 missense mutants and their long-timescale dynamics by atomistic molecular simulations and Markov state modeling
por: Pantsar, Tatu, et al.
Publicado: (2018)

Crystallographic Analysis of the Reaction Cycle of 2′,3′-Cyclic Nucleotide 3′-Phosphodiesterase, a Unique Member of the 2H Phosphoesterase Family
por: Myllykoski, Matti, et al.
Publicado: (2013)

Collapsin Response Mediator Protein-2 (CRMP2) is a Plausible Etiological Factor and Potential Therapeutic Target in Alzheimer’s Disease: Comparison and Contrast with Microtubule-Associated Protein Tau
por: Hensley, Kenneth, et al.
Publicado: (2016)

Reorganization of Lipid Diffusion by Myelin Basic Protein as Revealed by STED Nanoscopy
por: Steshenko, Olena, et al.
Publicado: (2016)

Neutron scattering
por: Celotta, Robert, et al.
Publicado: (1987)

Neutron scattering
por: Skoeld, Kurt, et al.
Publicado: (1987)

Neutron scattering
por: Skoeld, Kurt, et al.
Publicado: (1986)

Cannot write session to /tmp/vufind_sessions/sess_ovb4ar9s8pgu516h53o7h3u60m