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Body Mass Index Is Associated with Impaired Semen Characteristics and Reduced Levels of Anti-Müllerian Hormone across a Wide Weight Range

There is still controversy as to how body mass index (BMI) affects male reproduction. We investigated how BMI is associated with semen quality and reproductive hormones in 166 men, including 38 severely obese men. Standard semen analysis and sperm DNA integrity analysis were performed, and blood sam...

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Autores principales: Andersen, Jorunn M., Herning, Hilde, Aschim, Elin L., Hjelmesæth, Jøran, Mala, Tom, Hanevik, Hans Ivar, Bungum, Mona, Haugen, Trine B, Witczak, Oliwia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466334/
https://www.ncbi.nlm.nih.gov/pubmed/26067627
http://dx.doi.org/10.1371/journal.pone.0130210
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author Andersen, Jorunn M.
Herning, Hilde
Aschim, Elin L.
Hjelmesæth, Jøran
Mala, Tom
Hanevik, Hans Ivar
Bungum, Mona
Haugen, Trine B
Witczak, Oliwia
author_facet Andersen, Jorunn M.
Herning, Hilde
Aschim, Elin L.
Hjelmesæth, Jøran
Mala, Tom
Hanevik, Hans Ivar
Bungum, Mona
Haugen, Trine B
Witczak, Oliwia
author_sort Andersen, Jorunn M.
collection PubMed
description There is still controversy as to how body mass index (BMI) affects male reproduction. We investigated how BMI is associated with semen quality and reproductive hormones in 166 men, including 38 severely obese men. Standard semen analysis and sperm DNA integrity analysis were performed, and blood samples were analysed for reproductive hormones. Adjusted for age and time of abstinence, BMI was negatively associated with sperm concentration (B = -0.088, P = 0.009), total sperm count (B = -0.223, P = 0.001), progressive sperm motility (B = -0.675, P = 0.007), normal sperm morphology (B = -0.078, P = 0.001), and percentage of vital spermatozoa (B = -0.006, P = 0.027). A negative relationship was observed between BMI and total testosterone (B = -0.378, P < 0.001), sex hormone binding globulin (B = -0.572, P < 0.001), inhibin B (B = -3.120, P < 0.001) and anti-Müllerian hormone (AMH) (B = -0.009, P < 0.001). Our findings suggest that high BMI is negatively associated with semen characteristics and serum levels of AMH.
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spelling pubmed-44663342015-06-22 Body Mass Index Is Associated with Impaired Semen Characteristics and Reduced Levels of Anti-Müllerian Hormone across a Wide Weight Range Andersen, Jorunn M. Herning, Hilde Aschim, Elin L. Hjelmesæth, Jøran Mala, Tom Hanevik, Hans Ivar Bungum, Mona Haugen, Trine B Witczak, Oliwia PLoS One Research Article There is still controversy as to how body mass index (BMI) affects male reproduction. We investigated how BMI is associated with semen quality and reproductive hormones in 166 men, including 38 severely obese men. Standard semen analysis and sperm DNA integrity analysis were performed, and blood samples were analysed for reproductive hormones. Adjusted for age and time of abstinence, BMI was negatively associated with sperm concentration (B = -0.088, P = 0.009), total sperm count (B = -0.223, P = 0.001), progressive sperm motility (B = -0.675, P = 0.007), normal sperm morphology (B = -0.078, P = 0.001), and percentage of vital spermatozoa (B = -0.006, P = 0.027). A negative relationship was observed between BMI and total testosterone (B = -0.378, P < 0.001), sex hormone binding globulin (B = -0.572, P < 0.001), inhibin B (B = -3.120, P < 0.001) and anti-Müllerian hormone (AMH) (B = -0.009, P < 0.001). Our findings suggest that high BMI is negatively associated with semen characteristics and serum levels of AMH. Public Library of Science 2015-06-12 /pmc/articles/PMC4466334/ /pubmed/26067627 http://dx.doi.org/10.1371/journal.pone.0130210 Text en © 2015 Andersen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Andersen, Jorunn M.
Herning, Hilde
Aschim, Elin L.
Hjelmesæth, Jøran
Mala, Tom
Hanevik, Hans Ivar
Bungum, Mona
Haugen, Trine B
Witczak, Oliwia
Body Mass Index Is Associated with Impaired Semen Characteristics and Reduced Levels of Anti-Müllerian Hormone across a Wide Weight Range
title Body Mass Index Is Associated with Impaired Semen Characteristics and Reduced Levels of Anti-Müllerian Hormone across a Wide Weight Range
title_full Body Mass Index Is Associated with Impaired Semen Characteristics and Reduced Levels of Anti-Müllerian Hormone across a Wide Weight Range
title_fullStr Body Mass Index Is Associated with Impaired Semen Characteristics and Reduced Levels of Anti-Müllerian Hormone across a Wide Weight Range
title_full_unstemmed Body Mass Index Is Associated with Impaired Semen Characteristics and Reduced Levels of Anti-Müllerian Hormone across a Wide Weight Range
title_short Body Mass Index Is Associated with Impaired Semen Characteristics and Reduced Levels of Anti-Müllerian Hormone across a Wide Weight Range
title_sort body mass index is associated with impaired semen characteristics and reduced levels of anti-müllerian hormone across a wide weight range
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466334/
https://www.ncbi.nlm.nih.gov/pubmed/26067627
http://dx.doi.org/10.1371/journal.pone.0130210
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