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Computations underlying Drosophila photo-taxis, odor-taxis, and multi-sensory integration

To better understand how organisms make decisions on the basis of temporally varying multi-sensory input, we identified computations made by Drosophila larvae responding to visual and optogenetically induced fictive olfactory stimuli. We modeled the larva's navigational decision to initiate tur...

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Autores principales: Gepner, Ruben, Mihovilovic Skanata, Mirna, Bernat, Natalie M, Kaplow, Margarita, Gershow, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466338/
https://www.ncbi.nlm.nih.gov/pubmed/25945916
http://dx.doi.org/10.7554/eLife.06229
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author Gepner, Ruben
Mihovilovic Skanata, Mirna
Bernat, Natalie M
Kaplow, Margarita
Gershow, Marc
author_facet Gepner, Ruben
Mihovilovic Skanata, Mirna
Bernat, Natalie M
Kaplow, Margarita
Gershow, Marc
author_sort Gepner, Ruben
collection PubMed
description To better understand how organisms make decisions on the basis of temporally varying multi-sensory input, we identified computations made by Drosophila larvae responding to visual and optogenetically induced fictive olfactory stimuli. We modeled the larva's navigational decision to initiate turns as the output of a Linear-Nonlinear-Poisson cascade. We used reverse-correlation to fit parameters to this model; the parameterized model predicted larvae's responses to novel stimulus patterns. For multi-modal inputs, we found that larvae linearly combine olfactory and visual signals upstream of the decision to turn. We verified this prediction by measuring larvae's responses to coordinated changes in odor and light. We studied other navigational decisions and found that larvae integrated odor and light according to the same rule in all cases. These results suggest that photo-taxis and odor-taxis are mediated by a shared computational pathway. DOI: http://dx.doi.org/10.7554/eLife.06229.001
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spelling pubmed-44663382015-06-17 Computations underlying Drosophila photo-taxis, odor-taxis, and multi-sensory integration Gepner, Ruben Mihovilovic Skanata, Mirna Bernat, Natalie M Kaplow, Margarita Gershow, Marc eLife Neuroscience To better understand how organisms make decisions on the basis of temporally varying multi-sensory input, we identified computations made by Drosophila larvae responding to visual and optogenetically induced fictive olfactory stimuli. We modeled the larva's navigational decision to initiate turns as the output of a Linear-Nonlinear-Poisson cascade. We used reverse-correlation to fit parameters to this model; the parameterized model predicted larvae's responses to novel stimulus patterns. For multi-modal inputs, we found that larvae linearly combine olfactory and visual signals upstream of the decision to turn. We verified this prediction by measuring larvae's responses to coordinated changes in odor and light. We studied other navigational decisions and found that larvae integrated odor and light according to the same rule in all cases. These results suggest that photo-taxis and odor-taxis are mediated by a shared computational pathway. DOI: http://dx.doi.org/10.7554/eLife.06229.001 eLife Sciences Publications, Ltd 2015-05-06 /pmc/articles/PMC4466338/ /pubmed/25945916 http://dx.doi.org/10.7554/eLife.06229 Text en © 2015, Gepner et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Gepner, Ruben
Mihovilovic Skanata, Mirna
Bernat, Natalie M
Kaplow, Margarita
Gershow, Marc
Computations underlying Drosophila photo-taxis, odor-taxis, and multi-sensory integration
title Computations underlying Drosophila photo-taxis, odor-taxis, and multi-sensory integration
title_full Computations underlying Drosophila photo-taxis, odor-taxis, and multi-sensory integration
title_fullStr Computations underlying Drosophila photo-taxis, odor-taxis, and multi-sensory integration
title_full_unstemmed Computations underlying Drosophila photo-taxis, odor-taxis, and multi-sensory integration
title_short Computations underlying Drosophila photo-taxis, odor-taxis, and multi-sensory integration
title_sort computations underlying drosophila photo-taxis, odor-taxis, and multi-sensory integration
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466338/
https://www.ncbi.nlm.nih.gov/pubmed/25945916
http://dx.doi.org/10.7554/eLife.06229
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