Cargando…

Radotinib Induces Apoptosis of CD11b(+) Cells Differentiated from Acute Myeloid Leukemia Cells

Radotinib, developed as a BCR/ABL tyrosine kinase inhibitor (TKI), is approved for the second-line treatment of chronic myeloid leukemia (CML) in South Korea. However, therapeutic effects of radotinib in acute myeloid leukemia (AML) are unknown. In the present study, we demonstrate that radotinib si...

Descripción completa

Detalles Bibliográficos
Autores principales:	Heo, Sook-Kyoung, Noh, Eui-Kyu, Yoon, Dong-Joon, Jo, Jae-Cheol, Choi, Yunsuk, Koh, SuJin, Baek, Jin Ho, Park, Jae-Hoo, Min, Young Joo, Kim, Hawk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466365/ https://www.ncbi.nlm.nih.gov/pubmed/26065685 http://dx.doi.org/10.1371/journal.pone.0129853

Ejemplares similares

Targeting c-KIT (CD117) by dasatinib and radotinib promotes acute myeloid leukemia cell death
por: Heo, Sook-Kyoung, et al.
Publicado: (2017)

Author Correction: Targeting c-KIT (CD117) by dasatinib and radotinib promotes acute myeloid leukemia cell death
por: Heo, Sook-Kyoung, et al.
Publicado: (2021)

Radotinib inhibits multiple myeloma cell proliferation via suppression of STAT3 signaling
por: Heo, Sook-Kyoung, et al.
Publicado: (2022)

Radotinib enhances cytarabine (Ara-C)-induced acute myeloid leukemia cell death
por: Heo, Sook-Kyoung, et al.
Publicado: (2020)

The c-Abl inhibitor, radotinib induces apoptosis in multiple myeloma cells via mitochondrial-dependent pathway
por: Heo, Sook-Kyoung, et al.
Publicado: (2021)

Dasatinib Accelerates Valproic Acid-Induced Acute Myeloid Leukemia Cell Death by Regulation of Differentiation Capacity
por: Heo, Sook-Kyoung, et al.
Publicado: (2014)

LIGHT (TNFSF14) Increases the Survival and Proliferation of Human Bone Marrow-Derived Mesenchymal Stem Cells
por: Heo, Sook-Kyoung, et al.
Publicado: (2016)

CD45(dim)CD34(+)CD38(−)CD133(+) cells have the potential as leukemic stem cells in acute myeloid leukemia
por: Heo, Sook-Kyoung, et al.
Publicado: (2020)

LIGHT (TNFSF14) enhances osteogenesis of human bone marrow-derived mesenchymal stem cells
por: Heo, Sook-Kyoung, et al.
Publicado: (2021)

The soluble VCAM-1 level is a potential biomarker predicting severe acute graft versus host disease after allogeneic hematopoietic cell transplantation
por: Heo, Sook-Kyoung, et al.
Publicado: (2022)

Determination of a radotinib dosage regimen based on dose–response relationships for the treatment of newly diagnosed patients with chronic myeloid leukemia
por: Noh, Hayeon, et al.
Publicado: (2018)

Radotinib Decreases Prion Propagation and Prolongs Survival Times in Models of Prion Disease
por: Choi, Yeong-Gon, et al.
Publicado: (2023)

Long‐term data from a phase 3 study of radotinib versus imatinib in patients with newly diagnosed, chronic myeloid leukaemia in the chronic phase (RERISE)
por: Do, Young Rok, et al.
Publicado: (2020)

The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson’s disease mouse model
por: Lee, Saebom, et al.
Publicado: (2018)

Novel Application of Radotinib for the Treatment of Solid Tumors via Natural Killer Cell Activation
por: Kim, Kyung Eun, et al.
Publicado: (2018)

Radotinib attenuates TGFβ -mediated pulmonary fibrosis in vitro and in vivo: exploring the potential of drug repurposing
por: Baek, Suji, et al.
Publicado: (2022)

LIGHT (TNFSF14) promotes the differentiation of human bone marrow-derived mesenchymal stem cells into functional hepatocyte-like cells
por: Heo, Sook-Kyoung, et al.
Publicado: (2023)

Radotinib is an Effective Inhibitor of Native and Kinase Domain-Mutant BCR-ABL1
por: Zabriskie, Matthew S., et al.
Publicado: (2015)

Arsenic trioxide induces depolymerization of microtubules in an acute promyelocytic leukemia cell line
por: Baek, Jin Ho, et al.
Publicado: (2012)

Anorectal and gastric peripheral T-cell lymphoma, unspecified in a non-AIDS patient
por: Eum, Eun-A, et al.
Publicado: (2006)

Development and validation of analytical method for the determination of radotinib in human plasma using liquid chromatography-tandem mass spectrometry
por: Seo, Hyo-Bum, et al.
Publicado: (2017)

HLA-I-restricted CD8(+) T cell immunity may accelerate tumorigenesis in conjunction with VHL inactivation
por: Park, BeumJin, et al.
Publicado: (2022)

Exercise-induced changes in stress hormones and cell adhesion molecules in obese men
por: Park, Jinkyung, et al.
Publicado: (2018)

IDH1/2 mutations in acute myeloid leukemia
por: Byun, Ja Min, et al.
Publicado: (2022)

Changes in decision-making process for life-sustaining treatment in patients with advanced cancer after the life-sustaining treatment decisions-making act
por: Kim, Hyeyeong, et al.
Publicado: (2021)

Angioimmunoblastic T-Cell Lymphoma in a Patient with Klinefelter Syndrome
por: Park, Yong Tae, et al.
Publicado: (2016)

Prognostic stratification based on the levels of tumor-infiltrating myeloid-derived suppressor cells and PD-1/PD-L1 axis in locally advanced rectal cancer
por: Lim, Yu Jin, et al.
Publicado: (2022)

Dietary intake of fat and fatty acids by 1–5-year-old children in Korea: a cross-sectional study based on data from the sixth Korea National Health and Nutrition Examination Survey
por: Baek, YounJoo, et al.
Publicado: (2018)

Cell adhesion molecules and exercise
por: Koh, Yunsuk, et al.
Publicado: (2018)

The generation of stem cell-like memory cells early after BNT162b2 vaccination is associated with durability of memory CD8(+) T cell responses
por: Jung, Sungmin, et al.
Publicado: (2022)

NRF2 Knockdown Resensitizes 5-Fluorouracil-Resistant Pancreatic Cancer Cells by Suppressing HO-1 and ABCG2 Expression
por: Kim, Eui Joo, et al.
Publicado: (2020)

Prognostic significance of BLK expression in R-CHOP treated diffuse large B-cell lymphoma
por: Choi, Soyeon, et al.
Publicado: (2022)

Real-world management of chronic myeloid leukemia in South Korea: the TARGET survey
por: Uhm, Jieun, et al.
Publicado: (2021)

Bone marrow metastasis of small cell lung carcinoma with spontaneous tumor lysis syndrome without hepatic metastasis at diagnosis: first case report in Korea and review of literature
por: Park, Sang Hyuk, et al.
Publicado: (2019)

Clinical impact of anti-thymocyte globulin on survival and graft-versus-host disease in patients undergoing human leukocyte antigen mismatched allogeneic stem cell transplantation
por: Kim, Taeyun, et al.
Publicado: (2020)

FLT3 mutations in acute myeloid leukemia: a review focusing on clinically applicable drugs
por: Ahn, Jae-Sook, et al.
Publicado: (2022)

Clinical Features Reflect Exon Sites of EGFR Mutations in Patients with Resected Non-Small-Cell Lung Cancer
por: Na, Im II, et al.
Publicado: (2007)

Inhibitory effect of ginsenoside Rg3 on cancer stemness and mesenchymal transition in breast cancer via regulation of myeloid-derived suppressor cells
por: Song, Joong-Hyun, et al.
Publicado: (2020)

Profiling of Metabolic Differences between Hematopoietic Stem Cells and Acute/Chronic Myeloid Leukemia
por: Song, Byung Hoo, et al.
Publicado: (2020)

A phase 4 study of nilotinib in Korean patients with Philadelphia chromosome‐positive chronic myeloid leukemia in chronic phase: ENESTKorea
por: Shin, Junghoon, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_vqqugmb1ki12suln5lt3n0ci57