Interactions of Isophorone Derivatives with DNA: Spectroscopic Studies

Interactions of three new isophorone derivatives, Isoa Isob and Isoc with salmon testes DNA have been investigated using UV-Vis, fluorescence and circular dichroism spectroscopic methods. All the studied compounds interact with DNA through intercalative binding mode. The stoichiometry of the isophor...

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Autores principales: Deiana, Marco, Matczyszyn, Katarzyna, Massin, Julien, Olesiak-Banska, Joanna, Andraud, Chantal, Samoc, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466397/
https://www.ncbi.nlm.nih.gov/pubmed/26069963
http://dx.doi.org/10.1371/journal.pone.0129817
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author Deiana, Marco
Matczyszyn, Katarzyna
Massin, Julien
Olesiak-Banska, Joanna
Andraud, Chantal
Samoc, Marek
author_facet Deiana, Marco
Matczyszyn, Katarzyna
Massin, Julien
Olesiak-Banska, Joanna
Andraud, Chantal
Samoc, Marek
author_sort Deiana, Marco
collection PubMed
description Interactions of three new isophorone derivatives, Isoa Isob and Isoc with salmon testes DNA have been investigated using UV-Vis, fluorescence and circular dichroism spectroscopic methods. All the studied compounds interact with DNA through intercalative binding mode. The stoichiometry of the isophorone/DNA adducts was found to be 1:1. The fluorescence quenching data revealed a binding interaction with the base pairs of DNA. The CD data indicate that all the investigated isophorones induce DNA modifications.
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spelling pubmed-44663972015-06-22 Interactions of Isophorone Derivatives with DNA: Spectroscopic Studies Deiana, Marco Matczyszyn, Katarzyna Massin, Julien Olesiak-Banska, Joanna Andraud, Chantal Samoc, Marek PLoS One Research Article Interactions of three new isophorone derivatives, Isoa Isob and Isoc with salmon testes DNA have been investigated using UV-Vis, fluorescence and circular dichroism spectroscopic methods. All the studied compounds interact with DNA through intercalative binding mode. The stoichiometry of the isophorone/DNA adducts was found to be 1:1. The fluorescence quenching data revealed a binding interaction with the base pairs of DNA. The CD data indicate that all the investigated isophorones induce DNA modifications. Public Library of Science 2015-06-12 /pmc/articles/PMC4466397/ /pubmed/26069963 http://dx.doi.org/10.1371/journal.pone.0129817 Text en © 2015 Deiana et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Deiana, Marco
Matczyszyn, Katarzyna
Massin, Julien
Olesiak-Banska, Joanna
Andraud, Chantal
Samoc, Marek
Interactions of Isophorone Derivatives with DNA: Spectroscopic Studies
title Interactions of Isophorone Derivatives with DNA: Spectroscopic Studies
title_full Interactions of Isophorone Derivatives with DNA: Spectroscopic Studies
title_fullStr Interactions of Isophorone Derivatives with DNA: Spectroscopic Studies
title_full_unstemmed Interactions of Isophorone Derivatives with DNA: Spectroscopic Studies
title_short Interactions of Isophorone Derivatives with DNA: Spectroscopic Studies
title_sort interactions of isophorone derivatives with dna: spectroscopic studies
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466397/
https://www.ncbi.nlm.nih.gov/pubmed/26069963
http://dx.doi.org/10.1371/journal.pone.0129817
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