Cargando…

Spinoculation Enhances HBV Infection in NTCP-Reconstituted Hepatocytes

Hepatitis B virus (HBV) infection and its sequelae remain a major public health burden, but both HBV basic research and the development of antiviral therapeutics have been hindered by the lack of an efficient in vitro infection system. Recently, sodium taurocholate cotransporting polypeptide (NTCP)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yan, Ran, Zhang, Yongmei, Cai, Dawei, Liu, Yuanjie, Cuconati, Andrea, Guo, Haitao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466484/ https://www.ncbi.nlm.nih.gov/pubmed/26070202 http://dx.doi.org/10.1371/journal.pone.0129889

Ejemplares similares

Elevated NTCP expression by an iPSC-derived human hepatocyte maintenance medium enhances HBV infection in NTCP-reconstituted HepG2 cells
por: Li, Xinlei, et al.
Publicado: (2021)

Receptor-Independent Infection of Mouse Hepatitis Virus: Analysis by Spinoculation
por: Watanabe, Rie, et al.
Publicado: (2006)

High efficiency closed-system gene transfer using automated spinoculation
por: Remley, Victoria Ann, et al.
Publicado: (2021)

Genetic variations of NTCP are associated with susceptibility to HBV infection and related hepatocellular carcinoma
por: Wang, Peng, et al.
Publicado: (2017)

Tyrosine 146 of the Human Na(+)/Taurocholate Cotransporting Polypeptide (NTCP) Is Essential for Its Hepatitis B Virus (HBV) Receptor Function and HBV Entry into Hepatocytes
por: Zakrzewicz, Dariusz, et al.
Publicado: (2022)

Key Factors for “Fishing” NTCP as a Functional Receptor for HBV and HDV
por: Yan, Huan, et al.
Publicado: (2023)

Innovative HBV Animal Models Based on the Entry Receptor NTCP
por: Wettengel, Jochen M., et al.
Publicado: (2020)

Structural insights into the HBV receptor and bile acid transporter NTCP
por: Park, Jae-Hyun, et al.
Publicado: (2022)

Regulation of the HBV Entry Receptor NTCP and its Potential in Hepatitis B Treatment
por: Li, Yan, et al.
Publicado: (2022)

IFITM3 Interacts with the HBV/HDV Receptor NTCP and Modulates Virus Entry and Infection
por: Palatini, Massimo, et al.
Publicado: (2022)

A genetic variant of the NTCP gene is associated with HBV infection status in a Chinese population
por: Yang, Jingmin, et al.
Publicado: (2016)

Diverse Effects of the NTCP p.Ser267Phe Variant on Disease Progression During Chronic HBV Infection and on HBV preS1 Variability
por: Yang, Fangji, et al.
Publicado: (2019)

Productive HBV infection of well-differentiated, hNTCP-expressing human hepatoma-derived (Huh7) cells
por: Zhou, Ming, et al.
Publicado: (2017)

Down-regulation of cell membrane localized NTCP expression in proliferating hepatocytes prevents hepatitis B virus infection
por: Yan, Ying, et al.
Publicado: (2019)

Spinoculation and retronectin highly enhance the gene transduction efficiency of Mucin-1-specific chimeric antigen receptor (CAR) in human primary T cells
por: Rajabzadeh, Alireza, et al.
Publicado: (2021)

Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes
por: Verrier, Eloi R., et al.
Publicado: (2016)

Multitasking Na(+)/Taurocholate Cotransporting Polypeptide (NTCP) as a Drug Target for HBV Infection: From Protein Engineering to Drug Discovery
por: Zakrzewicz, Dariusz, et al.
Publicado: (2022)

hNTCP-expressing primary pig hepatocytes are a valuable tool for investigating hepatitis B virus infection and antiviral drugs
por: Zhou, Ming, et al.
Publicado: (2019)

Inhibition of Hepatitis B Virus Replication by the Host Zinc Finger Antiviral Protein
por: Mao, Richeng, et al.
Publicado: (2013)

In Vivo Models of HDV Infection: Is Humanizing NTCP Enough?
por: Giersch, Katja, et al.
Publicado: (2021)

Immunopeptidome of hepatocytes isolated from patients with HBV infection and hepatocellular carcinoma
por: de Beijer, Monique T.A., et al.
Publicado: (2022)

Unlocking the secrets to human NTCP structure
por: Qi, Xiangbing, et al.
Publicado: (2022)

The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro
por: Gad, Sameh A., et al.
Publicado: (2022)

ACE2 and TMPRSS2 Expression in Hepatocytes of Chronic HBV Infection Patients
por: Hu, Xiao-Xiao, et al.
Publicado: (2021)

Human hepatocyte depletion in the presence of HIV-1 infection in dual reconstituted humanized mice
por: Dagur, Raghubendra Singh, et al.
Publicado: (2018)

HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways
por: Guo, Fang, et al.
Publicado: (2017)

The Interactions Between HBV and the Innate Immunity of Hepatocytes
por: Megahed, Fayed Attia Koutb, et al.
Publicado: (2020)

P73. Functional characterisation of HBV-specific T cell receptors for redirection of T cells against HBV infected hepatocytes
por: Krebs, K, et al.
Publicado: (2014)

Mechanistic insights into the inhibition of NTCP by myrcludex B
por: Donkers, Joanne M., et al.
Publicado: (2019)

Insufficient evidence for NTCP activity in stellate cells
por: Kunst, Roni F, et al.
Publicado: (2022)

NLRX1 can counteract innate immune response induced by an external stimulus favoring HBV infection by competitive inhibition of MAVS-RLRs signaling in HepG2-NTCP cells
por: Jiao, Qian, et al.
Publicado: (2021)

HBV integrated genomic characterization revealed hepatocyte genomic alterations in HBV-related hepatocellular carcinomas
por: Yang, Ming, et al.
Publicado: (2020)

The NTCP p.Ser267Phe Variant Is Associated With a Faster Anti-HBV Effect on First-Line Nucleos(t)ide Analog Treatment
por: Wu, Lina, et al.
Publicado: (2021)

NTCP Deficiency Causes Gallbladder Abnormalities in Mice and Human Beings
por: Mao, Fengfeng, et al.
Publicado: (2020)

Genomic responses to hepatitis B virus (HBV) infection in primary human hepatocytes
por: Ancey, Pierre-Benoit, et al.
Publicado: (2015)

Association of NTCP polymorphisms with clinical outcome of hepatitis B infection in Thai individuals
por: Chuaypen, Natthaya, et al.
Publicado: (2019)

NTCP deficiency in mice protects against obesity and hepatosteatosis
por: Donkers, Joanne M., et al.
Publicado: (2019)

NTCP Change in Rats of Hilar Cholangiocarcinoma and Therapeutic Significance
por: Zhang, Meng-yu, et al.
Publicado: (2022)

NTCP gene polymorphisms and hepatitis B virus infection status in a Ghanaian population
por: Nyarko, Eric, et al.
Publicado: (2020)

Identification of Therapeutic Targets for the Selective Killing of HBV-Positive Hepatocytes
por: Huang, Chien-Jung, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_0j7cp7h165t43dcm5bo35l63a6