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Seneca Valley Virus 3C(pro) Substrate Optimization Yields Efficient Substrates for Use in Peptide-Prodrug Therapy
The oncolytic picornavirus Seneca Valley Virus (SVV-001) demonstrates anti-tumor activity in models of small cell lung cancer (SCLC), but may ultimately need to be combined with cytotoxic therapies to improve responses observed in patients. Combining SVV-001 virotherapy with a peptide prodrug activa...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466507/ https://www.ncbi.nlm.nih.gov/pubmed/26069962 http://dx.doi.org/10.1371/journal.pone.0129103 |