Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton-Sensing GPR4 in Extracellular Acidification-Induced Responses

G protein-coupled receptor 4 (GPR4), previously proposed as the receptor for sphingosylphosphorylcholine, has recently been identified as the proton-sensing G protein-coupled receptor (GPCR) coupling to multiple intracellular signaling pathways, including the G(s) protein/cAMP and G(13) protein/Rho....

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Detalles Bibliográficos
Autores principales: Tobo, Ayaka, Tobo, Masayuki, Nakakura, Takashi, Ebara, Masashi, Tomura, Hideaki, Mogi, Chihiro, Im, Dong-Soon, Murata, Naoya, Kuwabara, Atsushi, Ito, Saki, Fukuda, Hayato, Arisawa, Mitsuhiro, Shuto, Satoshi, Nakaya, Michio, Kurose, Hitoshi, Sato, Koichi, Okajima, Fumikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466532/
https://www.ncbi.nlm.nih.gov/pubmed/26070068
http://dx.doi.org/10.1371/journal.pone.0129334

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