Cargando…
P-selectin-mediated platelet adhesion promotes tumor growth
Blood platelets foster carcinogenesis. We found that platelets are accumulated in human tumors. P-selectin deficiency and soluble P-selectin abolish platelet deposition within tumors, decreasing secretion of vascular endothelial growth factor and angiogenesis, thereby suppressing tumor growth. Bindi...
| Autores principales: | , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466636/ https://www.ncbi.nlm.nih.gov/pubmed/25762641 |
| _version_ | 1782376260075257856 |
|---|---|
| author | Qi, Cuiling Wei, Bo Zhou, Weijie Yang, Yang Li, Bin Guo, Simei Li, Jialin Ye, Jie Li, Jiangchao Zhang, Qianqian Lan, Tian He, Xiaodong Cao, Liu Zhou, Jia Geng, Jianguo Wang, Lijing |
| author_facet | Qi, Cuiling Wei, Bo Zhou, Weijie Yang, Yang Li, Bin Guo, Simei Li, Jialin Ye, Jie Li, Jiangchao Zhang, Qianqian Lan, Tian He, Xiaodong Cao, Liu Zhou, Jia Geng, Jianguo Wang, Lijing |
| author_sort | Qi, Cuiling |
| collection | PubMed |
| description | Blood platelets foster carcinogenesis. We found that platelets are accumulated in human tumors. P-selectin deficiency and soluble P-selectin abolish platelet deposition within tumors, decreasing secretion of vascular endothelial growth factor and angiogenesis, thereby suppressing tumor growth. Binding of the P-selectin cytoplasmic tail to talin1 triggers the talin1 N-terminal head to interact with the β3 cytoplasmic tail. This activates αIIbβ3 and recruits platelets into tumors. Platelet infiltration into solid tumors occurs through a P-selectin-dependent mechanism. |
| format | Online Article Text |
| id | pubmed-4466636 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | Impact Journals LLC |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-44666362015-06-22 P-selectin-mediated platelet adhesion promotes tumor growth Qi, Cuiling Wei, Bo Zhou, Weijie Yang, Yang Li, Bin Guo, Simei Li, Jialin Ye, Jie Li, Jiangchao Zhang, Qianqian Lan, Tian He, Xiaodong Cao, Liu Zhou, Jia Geng, Jianguo Wang, Lijing Oncotarget Research Paper Blood platelets foster carcinogenesis. We found that platelets are accumulated in human tumors. P-selectin deficiency and soluble P-selectin abolish platelet deposition within tumors, decreasing secretion of vascular endothelial growth factor and angiogenesis, thereby suppressing tumor growth. Binding of the P-selectin cytoplasmic tail to talin1 triggers the talin1 N-terminal head to interact with the β3 cytoplasmic tail. This activates αIIbβ3 and recruits platelets into tumors. Platelet infiltration into solid tumors occurs through a P-selectin-dependent mechanism. Impact Journals LLC 2015-02-09 /pmc/articles/PMC4466636/ /pubmed/25762641 Text en Copyright: © 2015 Qi et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| spellingShingle | Research Paper Qi, Cuiling Wei, Bo Zhou, Weijie Yang, Yang Li, Bin Guo, Simei Li, Jialin Ye, Jie Li, Jiangchao Zhang, Qianqian Lan, Tian He, Xiaodong Cao, Liu Zhou, Jia Geng, Jianguo Wang, Lijing P-selectin-mediated platelet adhesion promotes tumor growth |
| title | P-selectin-mediated platelet adhesion promotes tumor growth |
| title_full | P-selectin-mediated platelet adhesion promotes tumor growth |
| title_fullStr | P-selectin-mediated platelet adhesion promotes tumor growth |
| title_full_unstemmed | P-selectin-mediated platelet adhesion promotes tumor growth |
| title_short | P-selectin-mediated platelet adhesion promotes tumor growth |
| title_sort | p-selectin-mediated platelet adhesion promotes tumor growth |
| topic | Research Paper |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466636/ https://www.ncbi.nlm.nih.gov/pubmed/25762641 |
| work_keys_str_mv | AT qicuiling pselectinmediatedplateletadhesionpromotestumorgrowth AT weibo pselectinmediatedplateletadhesionpromotestumorgrowth AT zhouweijie pselectinmediatedplateletadhesionpromotestumorgrowth AT yangyang pselectinmediatedplateletadhesionpromotestumorgrowth AT libin pselectinmediatedplateletadhesionpromotestumorgrowth AT guosimei pselectinmediatedplateletadhesionpromotestumorgrowth AT lijialin pselectinmediatedplateletadhesionpromotestumorgrowth AT yejie pselectinmediatedplateletadhesionpromotestumorgrowth AT lijiangchao pselectinmediatedplateletadhesionpromotestumorgrowth AT zhangqianqian pselectinmediatedplateletadhesionpromotestumorgrowth AT lantian pselectinmediatedplateletadhesionpromotestumorgrowth AT hexiaodong pselectinmediatedplateletadhesionpromotestumorgrowth AT caoliu pselectinmediatedplateletadhesionpromotestumorgrowth AT zhoujia pselectinmediatedplateletadhesionpromotestumorgrowth AT gengjianguo pselectinmediatedplateletadhesionpromotestumorgrowth AT wanglijing pselectinmediatedplateletadhesionpromotestumorgrowth |