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Triple Akt inhibition as a new therapeutic strategy in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive neoplastic disorder in which chemotherapy resistance and refractory relapses occur, with a poorer prognostic outcome. Constitutively active PI3K/Akt/mTOR pathway is a common feature of T-ALL upregulating cell proliferation, survival and dr...

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Detalles Bibliográficos
Autores principales:	Cani, Alice, Simioni, Carolina, Martelli, Alberto M., Zauli, Giorgio, Tabellini, Giovanna, Ultimo, Simona, McCubrey, James A., Capitani, Silvano, Neri, Luca M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466637/ https://www.ncbi.nlm.nih.gov/pubmed/25788264

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