Loss of p21(Cip1/CDKN1A) renders cancer cells susceptible to Polo-like kinase 1 inhibition

The deregulation of Polo-like kinase 1 is inversely linked to the prognosis of patients with diverse human tumors. Targeting Polo-like kinase 1 has been widely considered as one of the most promising strategies for molecular anticancer therapy. While the preclinical results are encouraging, the clin...

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Detalles Bibliográficos
Autores principales: Kreis, Nina-Naomi, Louwen, Frank, Zimmer, Brigitte, Yuan, Juping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466638/
https://www.ncbi.nlm.nih.gov/pubmed/25483104

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