Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status

Most cancers rely on aerobic glycolysis to generate energy and metabolic intermediates. To maintain a high glycolytic rate, cells must efficiently export lactic acid through the proton-coupled monocarboxylate transporters (MCT1/4). These transporters require a chaperone, CD147/BASIGIN (BSG) for traf...

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Detalles Bibliográficos
Autores principales: Granja, Sara, Marchiq, Ibtissam, Floch, Renaud Le, Moura, Conceição Souto, Baltazar, Fátima, Pouysségur, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466644/
https://www.ncbi.nlm.nih.gov/pubmed/25894929

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