Computational design, chemical synthesis, and biological evaluation of a novel ERK inhibitor (BL-EI001) with apoptosis-inducing mechanisms in breast cancer

Extracellular signal-regulated kinase1/2 (ERK1/2) plays a crucial role in the resistance of apoptosis in carcinogenesis; however, its targeted small-molecule inhibitors still remain to be discovered. Thus, in this study, we computationally and experimentally screened a series of small-molecule inhib...

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Detalles Bibliográficos
Autores principales: Liu, Bo, Fu, Leilei, Zhang, Cui, Zhang, Lan, Zhang, Yonghui, Ouyang, Liang, He, Gu, Huang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466648/
https://www.ncbi.nlm.nih.gov/pubmed/25742792

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