H89 enhances the sensitivity of cancer cells to glyceryl trinitrate through a purinergic receptor-dependent pathway

High doses of the organic nitrate glyceryl trinitrate (GTN), a nitric oxide (NO) donor, are known to trigger apoptosis in human cancer cells. Here, we show that such a cytotoxic effect can be obtained with subtoxic concentrations of GTN when combined with H89, N-[2-(p-bromocinnamylamino)ethyl]-5-iso...

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Detalles Bibliográficos
Autores principales: Cortier, Marion, Boina-Ali, Rahamata, Racoeur, Cindy, Paul, Catherine, Solary, Eric, Jeannin, Jean-François, Bettaieb, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466656/
https://www.ncbi.nlm.nih.gov/pubmed/25762630

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