DC120, a novel AKT inhibitor, preferentially suppresses nasopharyngeal carcinoma cancer stem-like cells by downregulating Sox2

Side population (SP) contains cancer stem-like cells (CSLCs). In this study, we characterized SP cells from nasopharyngeal carcinoma (NPC) cell lines and found that SP cells had a higher self-renewal ability in vitro and greater tumorigenicity in vivo. The AKT pathway was activated in NPC SP cells....

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Detalles Bibliográficos
Autores principales: Qin, Juan, Ji, Jiao, Deng, Rong, Tang, Jun, Yang, Fen, Feng, Gong-Kan, Chen, Wen-Dan, Wu, Xiao-Qi, Qian, Xiao-Jun, Ding, Ke, Zhu, Xiao-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466661/
https://www.ncbi.nlm.nih.gov/pubmed/25749514

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