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ZBRK1, a novel tumor suppressor, activates VHL gene transcription through formation of a complex with VHL and p300 in renal cancer

Inactivation or mutation of the VHL gene causes various tumors, including clear cell renal cell carcinoma (ccRCC). In the present study, we identified ZBRK1 as a novel VHL interacting protein by yeast two-hybrid screening, and found a single ZBRK1-binding site located in the VHL promoter region. Ect...

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Detalles Bibliográficos
Autores principales:	Chen, Ke, Yu, Gan, Gumireddy, Kiranmai, Li, Anping, Yao, Weimin, Gao, Lu, Chen, Shuliang, Hao, Jun, Wang, Ji, Huang, Qihong, Xu, Hua, Ye, Zhangqun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466662/ https://www.ncbi.nlm.nih.gov/pubmed/25749518

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