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A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties

The dynamic balance of cellular sphingolipids, the sphingolipid rheostat, is an important determinant of cell fate, and is commonly deregulated in cancer. Sphingosine 1-phosphate is a signaling molecule with anti-apoptotic, pro-proliferative and pro-angiogenic effects, while conversely, ceramide and...

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Detalles Bibliográficos
Autores principales:	Pitman, Melissa R., Powell, Jason A., Coolen, Carl, Moretti, Paul A.B., Zebol, Julia R., Pham, Duyen H., Finnie, John W., Don, Anthony S., Ebert, Lisa M., Bonder, Claudine S., Gliddon, Briony L., Pitson, Stuart M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466670/ https://www.ncbi.nlm.nih.gov/pubmed/25788259

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