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Bee venom inhibits growth of human cervical tumors in mice
We studied whether bee venom (BV) inhibits cervical tumor growth through enhancement of death receptor (DR) expressions and inactivation of nuclear factor kappa B (NF-κB) in mice. In vivo study showed that BV (1 mg/kg) inhibited tumor growth. Similar inhibitory effects of BV on cancer growth in prim...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466684/ https://www.ncbi.nlm.nih.gov/pubmed/25730901 |
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author | Lee, Hye Lim Park, Sang Ho Kim, Tae Myoung Jung, Yu Yeon Park, Mi Hee Oh, Sang Hyun Yun, Hye Seok Jun, Hyung Ok Yoo, Hwan Soo Han, Sang-Bae Lee, Ung Soo Yoon, Joo Hee Song, Min Jong Hong, Jin Tae |
author_facet | Lee, Hye Lim Park, Sang Ho Kim, Tae Myoung Jung, Yu Yeon Park, Mi Hee Oh, Sang Hyun Yun, Hye Seok Jun, Hyung Ok Yoo, Hwan Soo Han, Sang-Bae Lee, Ung Soo Yoon, Joo Hee Song, Min Jong Hong, Jin Tae |
author_sort | Lee, Hye Lim |
collection | PubMed |
description | We studied whether bee venom (BV) inhibits cervical tumor growth through enhancement of death receptor (DR) expressions and inactivation of nuclear factor kappa B (NF-κB) in mice. In vivo study showed that BV (1 mg/kg) inhibited tumor growth. Similar inhibitory effects of BV on cancer growth in primary human cervical cancer cells were also found. BV (1–5 μg/ml) also inhibited the growth of cancer cells, Ca Ski and C33Aby the induction of apoptotic cell death in a dose dependent manner. Agreed with cancer cell growth inhibition, expression of death receptors; FAS, DR3 and DR6, and DR downstream pro-apoptotic proteins including caspase-3 and Bax was concomitantly increased, but the NF-κB activity and the expression of Bcl-2 were inhibited by treatment with BV in tumor mice, human cancer cell and human tumor samples as well as cultured cancer cells. In addition, deletion of FAS, DR3 and DR6 by small interfering RNA significantly reversed BV-induced cell growth inhibitory effects as well as NF-κB inactivation. These results suggest that BV inhibits cervical tumor growth through enhancement of FAS, DR3 and DR6 expression via inhibition of NF-κB pathway. |
format | Online Article Text |
id | pubmed-4466684 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-44666842015-06-22 Bee venom inhibits growth of human cervical tumors in mice Lee, Hye Lim Park, Sang Ho Kim, Tae Myoung Jung, Yu Yeon Park, Mi Hee Oh, Sang Hyun Yun, Hye Seok Jun, Hyung Ok Yoo, Hwan Soo Han, Sang-Bae Lee, Ung Soo Yoon, Joo Hee Song, Min Jong Hong, Jin Tae Oncotarget Research Paper We studied whether bee venom (BV) inhibits cervical tumor growth through enhancement of death receptor (DR) expressions and inactivation of nuclear factor kappa B (NF-κB) in mice. In vivo study showed that BV (1 mg/kg) inhibited tumor growth. Similar inhibitory effects of BV on cancer growth in primary human cervical cancer cells were also found. BV (1–5 μg/ml) also inhibited the growth of cancer cells, Ca Ski and C33Aby the induction of apoptotic cell death in a dose dependent manner. Agreed with cancer cell growth inhibition, expression of death receptors; FAS, DR3 and DR6, and DR downstream pro-apoptotic proteins including caspase-3 and Bax was concomitantly increased, but the NF-κB activity and the expression of Bcl-2 were inhibited by treatment with BV in tumor mice, human cancer cell and human tumor samples as well as cultured cancer cells. In addition, deletion of FAS, DR3 and DR6 by small interfering RNA significantly reversed BV-induced cell growth inhibitory effects as well as NF-κB inactivation. These results suggest that BV inhibits cervical tumor growth through enhancement of FAS, DR3 and DR6 expression via inhibition of NF-κB pathway. Impact Journals LLC 2015-01-23 /pmc/articles/PMC4466684/ /pubmed/25730901 Text en Copyright: © 2015 Lee et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Lee, Hye Lim Park, Sang Ho Kim, Tae Myoung Jung, Yu Yeon Park, Mi Hee Oh, Sang Hyun Yun, Hye Seok Jun, Hyung Ok Yoo, Hwan Soo Han, Sang-Bae Lee, Ung Soo Yoon, Joo Hee Song, Min Jong Hong, Jin Tae Bee venom inhibits growth of human cervical tumors in mice |
title | Bee venom inhibits growth of human cervical tumors in mice |
title_full | Bee venom inhibits growth of human cervical tumors in mice |
title_fullStr | Bee venom inhibits growth of human cervical tumors in mice |
title_full_unstemmed | Bee venom inhibits growth of human cervical tumors in mice |
title_short | Bee venom inhibits growth of human cervical tumors in mice |
title_sort | bee venom inhibits growth of human cervical tumors in mice |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466684/ https://www.ncbi.nlm.nih.gov/pubmed/25730901 |
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