BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met

Most growth factors are initially synthesized as precursor proteins and subsequently processed into their mature form by proteolytic cleavage, resulting in simultaneous removal of a pro-peptide. However, compared with that of mature form, the biological role of the pro-peptide is poorly understood....

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Detalles Bibliográficos
Autores principales: Mizui, Toshiyuki, Ishikawa, Yasuyuki, Kumanogoh, Haruko, Lume, Maria, Matsumoto, Tomoya, Hara, Tomoko, Yamawaki, Shigeto, Takahashi, Masami, Shiosaka, Sadao, Itami, Chiaki, Uegaki, Koichi, Saarma, Mart, Kojima, Masami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2015
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466729/
https://www.ncbi.nlm.nih.gov/pubmed/26015580
http://dx.doi.org/10.1073/pnas.1422336112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466729/
https://www.ncbi.nlm.nih.gov/pubmed/26015580
http://dx.doi.org/10.1073/pnas.1422336112

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