Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation

BRAF functions in the RAS-extracellular signal-regulated kinase (ERK) signaling cascade. Activation of this pathway is necessary to mediate the transforming potential of oncogenic BRAF, however, it may also cause a negative feedback that inhibits the epidermal growth factor receptor (EGFR). Mitogen-...

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Detalles Bibliográficos
Autores principales: Milewska, Malgorzata, Romano, David, Herrero, Ana, Guerriero, Maria Luisa, Birtwistle, Marc, Quehenberger, Franz, Hatzl, Stefan, Kholodenko, Boris N., Segatto, Oreste, Kolch, Walter, Zebisch, Armin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466796/
https://www.ncbi.nlm.nih.gov/pubmed/26065894
http://dx.doi.org/10.1371/journal.pone.0129859

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