HDAC1,2 inhibition impairs EZH2- and BBAP- mediated DNA repair to overcome chemoresistance in EZH2 gain-of-function mutant diffuse large B-cell lymphoma

Gain-of-function mutations in the catalytic site of EZH2 (Enhancer of Zeste Homologue 2), is observed in about 22% of diffuse large B-cell lymphoma (DLBCL) cases. Here we show that selective inhibition of histone deacetylase 1,2 (HDAC1,2) activity using a small molecule inhibitor causes cytotoxic or...

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Detalles Bibliográficos
Autores principales: Johnson, Danielle P., Spitz, Gabriella S., Tharkar, Shweta, Quayle, Steven N., Shearstone, Jeffrey R., Jones, Simon, McDowell, Maria E., Wellman, Hannah, Tyler, Jessica K., Cairns, Bradley R., Chandrasekharan, Mahesh B., Bhaskara, Srividya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467121/
https://www.ncbi.nlm.nih.gov/pubmed/25605023

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