Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1

FUSE-binding protein (FBP)-interacting repressor (FIR) is a c-myc transcriptional suppressor. A splice variant of FIR that lacks exon 2 in the transcriptional repressor domain (FIRΔexon2) upregulates c-myc transcription by inactivating wild-type FIR. The ratio of FIRΔexon2/FIR mRNA was increased in...

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Detalles Bibliográficos
Autores principales: Matsushita, Kazuyuki, Kitamura, Kouichi, Rahmutulla, Bahityar, Tanaka, Nobuko, Ishige, Takayuki, Satoh, Mamoru, Hoshino, Tyuji, Miyagi, Satoru, Mori, Takeshi, Itoga, Sakae, Shimada, Hideaki, Tomonaga, Takeshi, Kito, Minoru, Nakajima-Takagi, Yaeko, Kubo, Shuji, Nakaseko, Chiaki, Hatano, Masahiko, Miki, Takashi, Matsuo, Masafumi, Fukuyo, Masaki, Kaneda, Atsushi, Iwama, Atsushi, Nomura, Fumio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467136/
https://www.ncbi.nlm.nih.gov/pubmed/25671302

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