Identification of epipolythiodioxopiperazines HDN-1 and chaetocin as novel inhibitor of heat shock protein 90

The molecular chaperone heat shock protein 90 (Hsp90) has emerged as an important target for cancer treatment. HDN-1, an epipolythiopiperazine-2, 5-diones (ETPs) compound, was here identified as a new Hsp90 inhibitor. HDN-1 bound directly to C-terminus of Hsp90α, resulting in a potential conformatio...

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Detalles Bibliográficos
Autores principales: Song, Xiaoping, Zhao, Zhimin, Qi, Xin, Tang, Shuai, Wang, Qiang, Zhu, Tianjiao, Gu, Qianqun, Liu, Ming, Li, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467147/
https://www.ncbi.nlm.nih.gov/pubmed/25742791

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