Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure

Peripheral neural sensory mechanisms play a crucial role in metabolic regulation but less is known about the mechanisms underlying vagal sensing itself. Recently, we identified an enrichment of liver X receptor alpha and beta (LXRα/β) in the nodose ganglia of the vagus nerve. In this study, we show...

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Autores principales: Mansuy-Aubert, Virginie, Gautron, Laurent, Lee, Syann, Bookout, Angie L, Kusminski, Christine M, Sun, Kai, Zhang, Yuan, Scherer, Philipp E, Mangelsdorf, David J, Elmquist, Joel K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467361/
https://www.ncbi.nlm.nih.gov/pubmed/26076474
http://dx.doi.org/10.7554/eLife.06667
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author Mansuy-Aubert, Virginie
Gautron, Laurent
Lee, Syann
Bookout, Angie L
Kusminski, Christine M
Sun, Kai
Zhang, Yuan
Scherer, Philipp E
Mangelsdorf, David J
Elmquist, Joel K
author_facet Mansuy-Aubert, Virginie
Gautron, Laurent
Lee, Syann
Bookout, Angie L
Kusminski, Christine M
Sun, Kai
Zhang, Yuan
Scherer, Philipp E
Mangelsdorf, David J
Elmquist, Joel K
author_sort Mansuy-Aubert, Virginie
collection PubMed
description Peripheral neural sensory mechanisms play a crucial role in metabolic regulation but less is known about the mechanisms underlying vagal sensing itself. Recently, we identified an enrichment of liver X receptor alpha and beta (LXRα/β) in the nodose ganglia of the vagus nerve. In this study, we show mice lacking LXRα/β in peripheral sensory neurons have increased energy expenditure and weight loss when fed a Western diet (WD). Our findings suggest that the ability to metabolize and sense cholesterol and/or fatty acids in peripheral neurons is an important requirement for physiological adaptations to WDs. DOI: http://dx.doi.org/10.7554/eLife.06667.001
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spelling pubmed-44673612015-06-17 Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure Mansuy-Aubert, Virginie Gautron, Laurent Lee, Syann Bookout, Angie L Kusminski, Christine M Sun, Kai Zhang, Yuan Scherer, Philipp E Mangelsdorf, David J Elmquist, Joel K eLife Neuroscience Peripheral neural sensory mechanisms play a crucial role in metabolic regulation but less is known about the mechanisms underlying vagal sensing itself. Recently, we identified an enrichment of liver X receptor alpha and beta (LXRα/β) in the nodose ganglia of the vagus nerve. In this study, we show mice lacking LXRα/β in peripheral sensory neurons have increased energy expenditure and weight loss when fed a Western diet (WD). Our findings suggest that the ability to metabolize and sense cholesterol and/or fatty acids in peripheral neurons is an important requirement for physiological adaptations to WDs. DOI: http://dx.doi.org/10.7554/eLife.06667.001 eLife Sciences Publications, Ltd 2015-06-15 /pmc/articles/PMC4467361/ /pubmed/26076474 http://dx.doi.org/10.7554/eLife.06667 Text en © 2015, Mansuy-Aubert et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Mansuy-Aubert, Virginie
Gautron, Laurent
Lee, Syann
Bookout, Angie L
Kusminski, Christine M
Sun, Kai
Zhang, Yuan
Scherer, Philipp E
Mangelsdorf, David J
Elmquist, Joel K
Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure
title Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure
title_full Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure
title_fullStr Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure
title_full_unstemmed Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure
title_short Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure
title_sort loss of the liver x receptor lxrα/β in peripheral sensory neurons modifies energy expenditure
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467361/
https://www.ncbi.nlm.nih.gov/pubmed/26076474
http://dx.doi.org/10.7554/eLife.06667
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