Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling

In vivo functional investigation of oncogenes using somatic gene transfer has been successfully exploited to validate their role in tumorigenesis. For tumour suppressor genes this has proven more challenging due to technical aspects. To provide a flexible and effective method for investigating somat...

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Detalles Bibliográficos
Autores principales: Zuckermann, Marc, Hovestadt, Volker, Knobbe-Thomsen, Christiane B., Zapatka, Marc, Northcott, Paul A., Schramm, Kathrin, Belic, Jelena, Jones, David T. W., Tschida, Barbara, Moriarity, Branden, Largaespada, David, Roussel, Martine F., Korshunov, Andrey, Reifenberger, Guido, Pfister, Stefan M., Lichter, Peter, Kawauchi, Daisuke, Gronych, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467376/
https://www.ncbi.nlm.nih.gov/pubmed/26067104
http://dx.doi.org/10.1038/ncomms8391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467376/
https://www.ncbi.nlm.nih.gov/pubmed/26067104
http://dx.doi.org/10.1038/ncomms8391

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