Cargando…

Aberrant nuclear factor-kappa B activity in acute myeloid Leukemia: from molecular pathogenesis to therapeutic target

The overall survival of patients with acute myeloid leukemia (AML) has not been improved significantly over the last decade. Molecularly targeted agents hold promise to change the therapeutic landscape in AML. The nuclear factor kappa B (NF-κB) controls a plethora of biological process through switc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Jianbiao, Ching, Ying Qing, Chng, Wee-Joo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467382/ https://www.ncbi.nlm.nih.gov/pubmed/25823927

Ejemplares similares

Resistance to FLT3 inhibitors in acute myeloid leukemia: Molecular mechanisms and resensitizing strategies
por: Zhou, Jianbiao, et al.
Publicado: (2018)

Super-enhancers: critical roles and therapeutic targets in hematologic malignancies
por: Jia, Yunlu, et al.
Publicado: (2019)

X‐linked inhibitor of apoptosis inhibition sensitizes acute myeloid leukemia cell response to TRAIL and chemotherapy through potentiated induction of proapoptotic machinery
por: Zhou, Jianbiao, et al.
Publicado: (2017)

BET Bromodomain inhibition promotes De-repression of TXNIP and activation of ASK1-MAPK pathway in acute myeloid leukemia
por: Zhou, Yafeng, et al.
Publicado: (2018)

Inhibition of LIN28B impairs leukemia cell growth and metabolism in acute myeloid leukemia
por: Zhou, Jianbiao, et al.
Publicado: (2017)

Biological Hallmarks and Emerging Strategies to Target STAT3 Signaling in Multiple Myeloma
por: Zhou, Jianbiao, et al.
Publicado: (2022)

Nuclear Receptors as Potential Therapeutic Targets for Myeloid Leukemia
por: Pan, Pan, et al.
Publicado: (2020)

Novel mechanism of drug resistance to proteasome inhibitors in multiple myeloma
por: Zhou, Jianbiao, et al.
Publicado: (2019)

Functional Characterization of D9, a Novel Deazaneplanocin A (DZNep) Analog, in Targeting Acute Myeloid Leukemia (AML)
por: Jiang, Xia, et al.
Publicado: (2015)

NF-κB promotes the stem-like properties of leukemia cells by activation of LIN28B
por: Zhou, Jianbiao, et al.
Publicado: (2018)

Targeted Therapeutic Approach Based on Understanding of Aberrant Molecular Pathways Leading to Leukemic Proliferation in Patients with Acute Myeloid Leukemia
por: Song, Moo-Kon, et al.
Publicado: (2021)

Nuclear factor kappaB (NF-kappaB) pathway as a therapeutic target in rheumatoid arthritis.
por: Jue, D. M., et al.
Publicado: (1999)

Crosstalk between endoplasmic reticulum stress and oxidative stress: a dynamic duo in multiple myeloma
por: Xiong, Sinan, et al.
Publicado: (2021)

The pro-metastasis tyrosine phosphatase, PRL-3 (PTP4A3), is a novel mediator of oncogenic function of BCR-ABL in human chronic myeloid leukemia
por: Zhou, Jianbiao, et al.
Publicado: (2012)

LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells
por: Morgan, Rhys G., et al.
Publicado: (2019)

ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia
por: Zhou, Jianbiao, et al.
Publicado: (2019)

Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications
por: Takahashi, Shinichiro
Publicado: (2011)

The emerging roles of exosomes in leukemogeneis
por: Zhou, Jianbiao, et al.
Publicado: (2016)

Insights into the New Molecular Updates in Acute Myeloid Leukemia Pathogenesis
por: Demir, Derya
Publicado: (2023)

Cysteine‐rich protein 61 regulates the chemosensitivity of chronic myeloid leukemia to imatinib mesylate through the nuclear factor kappa B/Bcl‐2 pathway
por: Song, Yanfang, et al.
Publicado: (2019)

Molecular targeting in acute myeloid leukemia
por: Lim, Seah H., et al.
Publicado: (2017)

Molecular Pathogenesis of BCR-ABL-Negative Atypical Chronic Myeloid Leukemia
por: Fontana, Diletta, et al.
Publicado: (2021)

Homeobox gene expression in acute myeloid leukemia is linked to typical underlying molecular aberrations
por: Skvarova Kramarzova, Karolina, et al.
Publicado: (2014)

Therapeutic targeting of leukemia stem cells in acute myeloid leukemia
por: Barbosa, Karina, et al.
Publicado: (2023)

The significant role of redox system in myeloid leukemia: from pathogenesis to therapeutic applications
por: Kaweme, Natasha Mupeta, et al.
Publicado: (2020)

Tumor-derived exosomes in colorectal cancer progression and their clinical applications
por: Zhou, Jianbiao, et al.
Publicado: (2017)

STAT3: A Promising Therapeutic Target in Multiple Myeloma
por: Chong, Phyllis S. Y., et al.
Publicado: (2019)

Macrophages protect mycoplasma‐infected chronic myeloid leukemia cells from natural killer cell killing
por: Choo, Qing Wei Winnie, et al.
Publicado: (2020)

Molecular Therapeutic Approaches for Pediatric Acute Myeloid Leukemia
por: Tasian, Sarah K., et al.
Publicado: (2014)

Derepression of retroelements in acute myeloid leukemia with 3q aberrations
por: Mika, Jagoda, et al.
Publicado: (2021)

Emerging Epigenetic Therapeutic Targets in Acute Myeloid Leukemia
por: Wingelhofer, Bettina, et al.
Publicado: (2019)

Lysosomes in acute myeloid leukemia: potential therapeutic targets?
por: Rafiq, Sreoshee, et al.
Publicado: (2021)

Therapeutic Targeting of Acute Myeloid Leukemia by Gemtuzumab Ozogamicin
por: Gottardi, Michele, et al.
Publicado: (2021)

Targeting Nuclear Factor-Kappa B to Overcome Resistance to Chemotherapy
por: Godwin, P., et al.
Publicado: (2013)

Molecular genetic aberrations in the pathogenesis of multiple myeloma
por: Bong, Ivyna Pau Ni, et al.
Publicado: (2023)

Integrated nuclear proteomics and transcriptomics identifies S100A4 as a therapeutic target in acute myeloid leukemia
por: Alanazi, Bader, et al.
Publicado: (2019)

MMSET: Role and Therapeutic Opportunities in Multiple Myeloma
por: Xie, Zhigang, et al.
Publicado: (2014)

Single-cell genomic profiling of acute myeloid leukemia for clinical use: A pilot study
por: Yan, Benedict, et al.
Publicado: (2017)

The molecular pathogenesis of the NUP98-HOXA9 fusion protein in acute myeloid leukemia
por: Rio-Machin, A, et al.
Publicado: (2017)

Molecular Landscape of Acute Myeloid Leukemia: Prognostic and Therapeutic Implications
por: Marando, Ludovica, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_76i1i5v8bq02mtr9aq477h5ehr