Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression

Genomic instability (IN) is a common feature of many human cancers. The TP53 tumour suppressor gene is mutated in approximately half of human cancers. Here, we show that BRCA1 and RAD17 genes, whose derived proteins play a pivotal role in DNA damage repair, are transcriptional targets of gain-of-fun...

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Detalles Bibliográficos
Autores principales: Valenti, Fabio, Ganci, Federica, Fontemaggi, Giulia, Sacconi, Andrea, Strano, Sabrina, Blandino, Giovanni, Di Agostino, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467386/
https://www.ncbi.nlm.nih.gov/pubmed/25650659

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