Cell-specific expression of artificial microRNAs targeting essential genes exhibit potent antitumor effect on hepatocellular carcinoma cells

To achieve specific and potent antitumor effect of hepatocyte carcinoma cells, replication defective adenoviral vectors, namely rAd/AFP-amiRG, rAd/AFP-amiRE and rAd/AFP-amiRP, were constructed which were armed with artificial microRNAs (amiRs) targeting essential functional genes glyceraldehyde-3-ph...

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Detalles Bibliográficos
Autores principales: Mao, Chenyu, Liu, Hao, Chen, Ping, Ye, Jingjia, Teng, Lisong, Jia, Zhenyu, Cao, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467396/
https://www.ncbi.nlm.nih.gov/pubmed/25691059

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