EBNA3C regulates p53 through induction of Aurora kinase B

In multicellular organisms p53 maintains genomic integrity through activation of DNA repair, and apoptosis. EBNA3C can down regulate p53 transcriptional activity. Aurora kinase (AK) B phosphorylates p53, which leads to degradation of p53. Aberrant expression of AK-B is a hallmark of numerous human c...

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Detalles Bibliográficos
Autores principales: Jha, Hem C., Yang, Karren, El-Naccache, Darine W., Sun, Zhiguo, Robertson, Erle S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467402/
https://www.ncbi.nlm.nih.gov/pubmed/25691063

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