Granzyme M expressed by tumor cells promotes chemoresistance and EMT in vitro and metastasis in vivo associated with STAT3 activation

Granzyme M is a serine protease known to be often expressed by natural killer cells and induce target cells apoptosis in combination with perforin. However, we detected granzyme M expression in murine and human cancer cell lines and human tumor samples in our study. Granzyme M increased chemoresista...

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Autores principales: Wang, Huiru, Sun, Qing, Wu, Yanhong, Wang, Lin, Zhou, Chunxia, Ma, Wenbo, Zhang, Youhui, Wang, Shengdian, Zhang, Shuren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467404/
https://www.ncbi.nlm.nih.gov/pubmed/25788270
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author Wang, Huiru
Sun, Qing
Wu, Yanhong
Wang, Lin
Zhou, Chunxia
Ma, Wenbo
Zhang, Youhui
Wang, Shengdian
Zhang, Shuren
author_facet Wang, Huiru
Sun, Qing
Wu, Yanhong
Wang, Lin
Zhou, Chunxia
Ma, Wenbo
Zhang, Youhui
Wang, Shengdian
Zhang, Shuren
author_sort Wang, Huiru
collection PubMed
description Granzyme M is a serine protease known to be often expressed by natural killer cells and induce target cells apoptosis in combination with perforin. However, we detected granzyme M expression in murine and human cancer cell lines and human tumor samples in our study. Granzyme M increased chemoresistance, colony-formation, cytokine secretion and invasiveness in vitro. Most importantly, granzyme M facilitated tumor growth and metastasis in vivo. Granzyme M induced the epithelial-mesenchymal transition (EMT) in cancer cells associated with STAT3 activation. Our study revealed the role of granzyme M expressed by tumor in chemoresistance, invasion, metastasis and EMT.
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spelling pubmed-44674042015-06-22 Granzyme M expressed by tumor cells promotes chemoresistance and EMT in vitro and metastasis in vivo associated with STAT3 activation Wang, Huiru Sun, Qing Wu, Yanhong Wang, Lin Zhou, Chunxia Ma, Wenbo Zhang, Youhui Wang, Shengdian Zhang, Shuren Oncotarget Research Paper Granzyme M is a serine protease known to be often expressed by natural killer cells and induce target cells apoptosis in combination with perforin. However, we detected granzyme M expression in murine and human cancer cell lines and human tumor samples in our study. Granzyme M increased chemoresistance, colony-formation, cytokine secretion and invasiveness in vitro. Most importantly, granzyme M facilitated tumor growth and metastasis in vivo. Granzyme M induced the epithelial-mesenchymal transition (EMT) in cancer cells associated with STAT3 activation. Our study revealed the role of granzyme M expressed by tumor in chemoresistance, invasion, metastasis and EMT. Impact Journals LLC 2015-02-28 /pmc/articles/PMC4467404/ /pubmed/25788270 Text en Copyright: © 2015 Wang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Wang, Huiru
Sun, Qing
Wu, Yanhong
Wang, Lin
Zhou, Chunxia
Ma, Wenbo
Zhang, Youhui
Wang, Shengdian
Zhang, Shuren
Granzyme M expressed by tumor cells promotes chemoresistance and EMT in vitro and metastasis in vivo associated with STAT3 activation
title Granzyme M expressed by tumor cells promotes chemoresistance and EMT in vitro and metastasis in vivo associated with STAT3 activation
title_full Granzyme M expressed by tumor cells promotes chemoresistance and EMT in vitro and metastasis in vivo associated with STAT3 activation
title_fullStr Granzyme M expressed by tumor cells promotes chemoresistance and EMT in vitro and metastasis in vivo associated with STAT3 activation
title_full_unstemmed Granzyme M expressed by tumor cells promotes chemoresistance and EMT in vitro and metastasis in vivo associated with STAT3 activation
title_short Granzyme M expressed by tumor cells promotes chemoresistance and EMT in vitro and metastasis in vivo associated with STAT3 activation
title_sort granzyme m expressed by tumor cells promotes chemoresistance and emt in vitro and metastasis in vivo associated with stat3 activation
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467404/
https://www.ncbi.nlm.nih.gov/pubmed/25788270
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