Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer

Sporadic colorectal cancer (CRC) insurgence and progression depend on the activation of Wnt/β-catenin signaling. Dickkopf (DKK)-1 is an extracellular inhibitor of Wnt/β-catenin signaling that also has undefined β-catenin-independent actions. Here we report for the first time that a proportion of DKK...

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Detalles Bibliográficos
Autores principales: Aguilera, Óscar, González-Sancho, José Manuel, Zazo, Sandra, Rincón, Raúl, Fernández, Agustín F., Tapia, Olga, Canals, Francesc, Morte, Beatriz, Calvanese, Vincenzo, Orgaz, José L., Niell, Núria, Aguilar, Susana, Freije, José M., Graña, Osvaldo, Pisano, David G., Borrero, Aurea, Martínez-Useros, Javier, Jiménez, Benilde, Fraga, Mario F., García-Foncillas, Jesús, López-Otín, Carlos, Lafarga, Miguel, Rojo, Federico, Muñoz, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467410/
https://www.ncbi.nlm.nih.gov/pubmed/25788273

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