miR-1236 down-regulates alpha-fetoprotein, thus causing PTEN accumulation, which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells

Alpha fetoprotein (AFP) is a clinical biomarker of hepatocellular carcinoma (HCC). Here, we found that miR-1236 is down-regulated, whereas AFP is highly expressed in HCC tissues and cells. We demonstrated that miR-1236 directly targets the 3′UTR of AFP and down-regulates its expression. Also, miR-12...

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Detalles Bibliográficos
Autores principales: Gao, Rui, Cai, Chunli, Gan, Jiancheng, Yang, Xi, Shuang, Zeyu, Liu, Min, Li, Shengping, Tang, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467418/
https://www.ncbi.nlm.nih.gov/pubmed/25714026
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author Gao, Rui
Cai, Chunli
Gan, Jiancheng
Yang, Xi
Shuang, Zeyu
Liu, Min
Li, Shengping
Tang, Hua
author_facet Gao, Rui
Cai, Chunli
Gan, Jiancheng
Yang, Xi
Shuang, Zeyu
Liu, Min
Li, Shengping
Tang, Hua
author_sort Gao, Rui
collection PubMed
description Alpha fetoprotein (AFP) is a clinical biomarker of hepatocellular carcinoma (HCC). Here, we found that miR-1236 is down-regulated, whereas AFP is highly expressed in HCC tissues and cells. We demonstrated that miR-1236 directly targets the 3′UTR of AFP and down-regulates its expression. Also, miR-1236 inhibited and AFP stimulated proliferation, migration, invasion and vasculogenic mimicry (VM) of HCC. In agreement, AFP over-expression counteracted the inhibitory effect of miR-1236. We demonstrated that AFP promoted the ubiquitination of PTEN, thus decreasing PTEN levels, while miR-1236 inhibited the PI3K/Akt pathway.
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spelling pubmed-44674182015-06-22 miR-1236 down-regulates alpha-fetoprotein, thus causing PTEN accumulation, which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells Gao, Rui Cai, Chunli Gan, Jiancheng Yang, Xi Shuang, Zeyu Liu, Min Li, Shengping Tang, Hua Oncotarget Research Paper Alpha fetoprotein (AFP) is a clinical biomarker of hepatocellular carcinoma (HCC). Here, we found that miR-1236 is down-regulated, whereas AFP is highly expressed in HCC tissues and cells. We demonstrated that miR-1236 directly targets the 3′UTR of AFP and down-regulates its expression. Also, miR-1236 inhibited and AFP stimulated proliferation, migration, invasion and vasculogenic mimicry (VM) of HCC. In agreement, AFP over-expression counteracted the inhibitory effect of miR-1236. We demonstrated that AFP promoted the ubiquitination of PTEN, thus decreasing PTEN levels, while miR-1236 inhibited the PI3K/Akt pathway. Impact Journals LLC 2015-01-21 /pmc/articles/PMC4467418/ /pubmed/25714026 Text en Copyright: © 2015 Gao et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Gao, Rui
Cai, Chunli
Gan, Jiancheng
Yang, Xi
Shuang, Zeyu
Liu, Min
Li, Shengping
Tang, Hua
miR-1236 down-regulates alpha-fetoprotein, thus causing PTEN accumulation, which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells
title miR-1236 down-regulates alpha-fetoprotein, thus causing PTEN accumulation, which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells
title_full miR-1236 down-regulates alpha-fetoprotein, thus causing PTEN accumulation, which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells
title_fullStr miR-1236 down-regulates alpha-fetoprotein, thus causing PTEN accumulation, which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells
title_full_unstemmed miR-1236 down-regulates alpha-fetoprotein, thus causing PTEN accumulation, which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells
title_short miR-1236 down-regulates alpha-fetoprotein, thus causing PTEN accumulation, which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells
title_sort mir-1236 down-regulates alpha-fetoprotein, thus causing pten accumulation, which inhibits the pi3k/akt pathway and malignant phenotype in hepatoma cells
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467418/
https://www.ncbi.nlm.nih.gov/pubmed/25714026
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