Inhibition of Shp2 suppresses mutant EGFR-induced lung tumors in transgenic mouse model of lung adenocarcinoma

Epidermal growth factor receptor (EGFR) mutants drive lung tumorigenesis and are targeted for therapy. However, resistance to EGFR inhibitors has been observed, in which the mutant EGFR remains active. Thus, it is important to uncover mediators of EGFR mutant-driven lung tumors to develop new treatm...

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Detalles Bibliográficos
Autores principales: Schneeberger, Valentina E., Ren, Yuan, Luetteke, Noreen, Huang, Qingling, Chen, Liwei, Lawrence, Harshani R., Lawrence, Nicholas J., Haura, Eric B., Koomen, John M., Coppola, Domenico, Wu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467431/
https://www.ncbi.nlm.nih.gov/pubmed/25730908

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